Ito Christopher J, Reyes-Gelves Camilo, Perry Clayton, Kountakis Stilianos E
Department of Otolaryngology - Head and Neck Surgery, Augusta University, Augusta, GA, USA.
ORL J Otorhinolaryngol Relat Spec. 2017;79(6):331-335. doi: 10.1159/000484439. Epub 2017 Dec 6.
BACKGROUND/AIMS: Spontaneous cerebrospinal fluid (SCSF) leaks are associated with a high body mass index (BMI) and an expanded skull base. The purpose of this study is to determine if a correlation exists between BMI and olfactory fossa depth (OFD) in patients with SCSF leaks and those without.
This is a cross-sectional study evaluating the correlation between OFD and BMI in patients with and without SCSF leaks. OFD was measured on computed tomography obtained in temporal proximity to the BMI.
Patients with SCSF leaks had a deeper mean OFD than controls (6.39 vs. 5.46 mm, p = 0.013) and a larger BMI (38.2 vs. 30.5, p = 0.0003). Pearson correlation was positive between BMI and OFD in women from the control group (R = 0.319, n = 93, p = 0.002 on the left; R = 0.313, n = 93, p = 0.002 on the right) but insignificant in men.
The olfactory fossa is deeper and the BMI higher in patients with SCSF leaks than in those without. Differences were statistically significant. Higher BMI may predict deeper olfactory fossa in women but not in men. These findings suggest expansion of weak points in the skull base as precursors to the development of SCSF leaks in response to elevated CSF pressures, particularly in women.
背景/目的：自发性脑脊液（SCSF）漏与高体重指数（BMI）和扩大的颅底相关。本研究的目的是确定SCSF漏患者和非SCSF漏患者的BMI与嗅窝深度（OFD）之间是否存在相关性。
这是一项横断面研究，评估有和没有SCSF漏的患者中OFD与BMI之间的相关性。OFD是在与BMI测量时间相近的计算机断层扫描上测量的。
SCSF漏患者的平均OFD比对照组更深（6.39对5.46mm，p = 0.013），BMI更大（38.2对30.5，p = 0.0003）。对照组女性的BMI与OFD之间存在正相关（左侧R = 0.319，n = 93，p = 0.002；右侧R = 0.313，n = 93，p = 0.002），但男性中无显著相关性。
SCSF漏患者的嗅窝比无SCSF漏患者更深，BMI更高。差异具有统计学意义。较高的BMI可能预示女性的嗅窝更深，但男性并非如此。这些发现表明颅底薄弱点的扩大是SCSF漏发生发展的先兆，尤其是在女性中，这是对脑脊液压力升高的反应。
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