Caleffi M, Fentiman I S, Birkhead B G
Clinical Oncology Unit, Guy's Hospital, London, U.K.
Eur J Cancer Clin Oncol. 1989 Jan;25(1):51-6. doi: 10.1016/0277-5379(89)90050-3.
Presentation data on 607 breast cancer patients treated by a variety of modalities at Guy's Hospital, London, have been analysed using the Cox proportional hazards model, to identify factors associated with length of overall survival. When deaths attributable to causes other than breast cancer were treated as censoring events, the significant factors were found to be stage, mode of treatment, menstrual status and tumour size. The analysis was repeated for the subgroup of 326 patients treated by modified radical mastectomy. Four variables: stage, age at menarche, menstrual status and age were found to be significantly associated with both overall survival and length of distant recurrence-free interval. These factors have been combined to create a prognostic index which has been used to define subgroups of patients with different prognosis. The index has been validated on a separate group of 457 modified radical mastectomy patients treated at the same hospital.
已运用Cox比例风险模型分析了伦敦盖伊医院采用多种治疗方式治疗的607例乳腺癌患者的呈现数据，以确定与总生存时长相关的因素。当将归因于乳腺癌以外原因的死亡视为删失事件时，发现显著因素为分期、治疗方式、月经状态和肿瘤大小。对接受改良根治性乳房切除术治疗的326例患者亚组重复了该分析。发现四个变量：分期、初潮年龄、月经状态和年龄与总生存及远处无复发生存期时长均显著相关。这些因素已被综合起来创建了一个预后指数，该指数已用于定义具有不同预后的患者亚组。该指数已在同一医院接受治疗的另一组457例改良根治性乳房切除术患者中得到验证。
