Sun Belinda L, Jain Richa, Patel Charmi, Bhattacharyya Achyut K
1 Banner-University Medical Center Tucson, AZ, USA.
Int J Surg Pathol. 2018 Jun;26(4):347-352. doi: 10.1177/1066896917746745. Epub 2017 Dec 5.
Gastrointestinal (GI) graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infection often simulate each other. However, distinction between GVHD and CMV infection is critical in the management of immunosuppression for transplant recipients. This study retrospectively reviewed 16 patients diagnosed with GVHD from 2010 to 2016 and found 4 cases (25%) coinfected with CMV. Two cases were initially diagnosed as GVHD only but found to have CMV infection by serological testing within 3 days after immunosuppression treatment for GVHD. The remarkable histological feature of CMV infection appeared to be significant acute inflammation in addition to apoptotic epithelial injuries, and particularly in an early stage of CMV replication, acute inflammation is possibly the only detectable feature of CMV infection.
胃肠道移植物抗宿主病（GVHD）和巨细胞病毒（CMV）感染常常相互类似。然而，区分GVHD和CMV感染对于移植受者免疫抑制的管理至关重要。本研究回顾性分析了2010年至2016年期间诊断为GVHD的16例患者，发现4例（25%）合并CMV感染。2例最初仅诊断为GVHD，但在接受GVHD免疫抑制治疗后3天内通过血清学检测发现CMV感染。CMV感染显著的组织学特征除了凋亡性上皮损伤外，似乎还有明显的急性炎症，特别是在CMV复制的早期阶段，急性炎症可能是CMV感染唯一可检测到的特征。
