Computational Intelligence and Bioinformatics Lab, Department of Computer Science, Jamia Millia Islamia, New Delhi, 110025, India.
Computational Intelligence and Bioinformatics Lab, Department of Computer Science, Jamia Millia Islamia, New Delhi, 110025, India.
Biomed Pharmacother. 2017 Dec;96:1513-1526. doi: 10.1016/j.biopha.2017.11.103. Epub 2017 Dec 6.
Ebola virus (EBOV), a member of Filoviridae virus family under the genus Ebolavirus, has emerged as a dangerous and potential threat to human health globally. It causes a severe and deadly hemorrhagic fever in humans and other mammals, called Ebola Virus Disease (EVD). In recent outbreaks of EVD, there has been loss of large numbers of individual's life. Therefore, EBOV has attracted researchers and increased interests in developing new models for virus evolution, and therapies. The EBOV interacts with the immune system of the host which led to understand how the virus functions and effects immune system behaviour. This article presents an exhaustive review on Ebola research which includes EVD illness, symptoms, transmission patterns, patho-physiology conditions, development of antiviral agents and vaccines, resilient health system, dynamics and mathematical model of EBOV, challenges and prospects for future studies.
埃博拉病毒(EBOV)是丝状病毒科下埃博拉病毒属的一员,已成为对全球人类健康的一种危险且潜在的威胁。它会导致人类和其他哺乳动物发生严重且致命的出血热,即埃博拉病毒病(EVD)。在最近的几次 EVD 暴发中,有大量个体失去了生命。因此,EBOV 引起了研究人员的关注,并增加了他们开发新的病毒进化模型和疗法的兴趣。EBOV 与宿主的免疫系统相互作用,这有助于了解病毒的功能以及对免疫系统行为的影响。本文对埃博拉病毒研究进行了全面综述,其中包括 EVD 疾病、症状、传播模式、病理生理学状况、抗病毒药物和疫苗的开发、弹性卫生系统、EBOV 的动力学和数学模型、未来研究的挑战和前景。