• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

非特异性间质性肺炎与肺淋巴滤泡内 CD20+ B 淋巴细胞存在的相关性。

Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles.

机构信息

Division of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

出版信息

Sci Rep. 2017 Dec 5;7(1):16912. doi: 10.1038/s41598-017-17208-1.

DOI:10.1038/s41598-017-17208-1
PMID:29208971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5717047/
Abstract

Nonspecific interstitial pneumonia (NSIP) is characterised by interstitial infiltration of lymphocytes and varying amounts of interstitial fibrosis. B cells have been suggested to contribute to the pathogenesis of NSIP. However, the relationship between B-lymphocyte and the clinical outcomes of NSIP was unclear. In this study, 50 patients with histopathologically confirmed NSIP from Peking Union Medical College Hospital between April 2003 to December 2012 were retrospectively analyzed. Using immunohistochemical analyses, CD20+ B cells were counted in the lymphoid follicles, perivascular, interstitial, and peribronchiolar regions of lung tissure. The CD20+ lymphocytes were mainly present in the lymphoid follicles. The number of follicular CD20+ lymphocytes was higher in the fibrosing than cellular NSIP pattern [255.08 (132.92-449.71) vs. 121.33 (63.54-282.88)/0.1 mm, p = 0.017]. After 1 year of therapy, the follicular CD20+ lymphocytes were significantly higher in patients whose forced vital capacity (FVC) worsened as compared to those who improved (p = 0.014). Additionally, follicular CD20+ lymphocytes were negatively correlated with the post-treatment percentage change in FVC (rho = -0.397, p = 0.004). However, follicular CD20+ lymphocytes were not correlated with survival. These results suggested that pulmonary follicular CD20+ lymphocytes were correlated with the fibrosing pattern of NSIP and predicted less clinical improvement after treatment.

摘要

特发性非特异性间质性肺炎（NSIP）的特征是淋巴细胞间质浸润和不同程度的间质纤维化。有研究提示 B 细胞可能参与 NSIP 的发病机制。然而，B 淋巴细胞与 NSIP 临床结局的关系尚不清楚。本研究回顾性分析了 2003 年 4 月至 2012 年 12 月期间北京协和医院经组织病理学证实的 50 例 NSIP 患者。采用免疫组化分析，在肺组织的淋巴滤泡、血管周围、间质和细支气管周围区域计数 CD20+B 细胞。CD20+淋巴细胞主要存在于淋巴滤泡中。纤维性 NSIP 模式中滤泡性 CD20+淋巴细胞数量高于细胞性 NSIP 模式[255.08（132.92-449.71）比 121.33（63.54-282.88）/0.1mm，p=0.017]。治疗 1 年后，与治疗后用力肺活量（FVC）改善的患者相比，FVC 恶化的患者滤泡性 CD20+淋巴细胞明显更高（p=0.014）。此外，滤泡性 CD20+淋巴细胞与治疗后 FVC 的百分比变化呈负相关（rho=-0.397，p=0.004）。然而，滤泡性 CD20+淋巴细胞与生存率无关。这些结果表明，肺滤泡性 CD20+淋巴细胞与 NSIP 的纤维性模式相关，并预测治疗后临床改善较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/041931da03d8/41598_2017_17208_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/57baa8943f6e/41598_2017_17208_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/5c94de7eadae/41598_2017_17208_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/041931da03d8/41598_2017_17208_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/57baa8943f6e/41598_2017_17208_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/5c94de7eadae/41598_2017_17208_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4bf/5717047/041931da03d8/41598_2017_17208_Fig3_HTML.jpg

相似文献

1
Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles.非特异性间质性肺炎与肺淋巴滤泡内 CD20+ B 淋巴细胞存在的相关性。
Sci Rep. 2017 Dec 5;7(1):16912. doi: 10.1038/s41598-017-17208-1.
2
Clinical profile of unclassifiable interstitial lung disease: Comparison with chronic fibrosing idiopathic interstitial pneumonias.无法分类的间质性肺疾病的临床特征：与慢性纤维化性特发性间质性肺炎的比较。
J Int Med Res. 2018 Jan;46(1):448-456. doi: 10.1177/0300060517719767. Epub 2017 Jul 31.
3
Immunophenotyping and remodeling process in small airways of idiopathic interstitial pneumonias: functional and prognostic significance.特发性间质性肺炎小气道的免疫表型及重塑过程：功能及预后意义
Clin Respir J. 2008 Oct;2(4):227-38. doi: 10.1111/j.1752-699X.2008.00077.x.
4
Clinical, radiological, and pathological evaluation of "NSIP with OP overlap" pattern compared with NSIP in patients with idiopathic interstitial pneumonias.特发性间质性肺炎中“NSIP 重叠 OP 模式”与 NSIP 的临床、放射学和病理学评估。
Respir Med. 2020 Nov-Dec;174:106201. doi: 10.1016/j.rmed.2020.106201. Epub 2020 Oct 21.
5
Pathologically proved nonspecific interstitial pneumonia: CT pattern analysis as compared with usual interstitial pneumonia CT pattern.经病理证实的非特异性间质性肺炎：与普通间质性肺炎 CT 模式的比较分析。
Radiology. 2014 Aug;272(2):549-56. doi: 10.1148/radiol.14130853. Epub 2014 Mar 22.
6
Morphologic and quantitative assessment of CD20+ B cell infiltrates in rheumatoid arthritis-associated nonspecific interstitial pneumonia and usual interstitial pneumonia.类风湿关节炎相关非特异性间质性肺炎和普通间质性肺炎中CD20+B细胞浸润的形态学和定量评估
Arthritis Rheum. 2006 Feb;54(2):635-41. doi: 10.1002/art.21758.
7
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias.特发性间质性肺炎中未分化结缔组织病的更广泛标准。
Respir Med. 2015 Mar;109(3):389-96. doi: 10.1016/j.rmed.2015.01.009. Epub 2015 Jan 31.
8
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.抗氨酰基-tRNA 合成酶抗体相关性与特发性非特异性间质性肺炎的比较。
Respir Med. 2019 Jun;152:44-50. doi: 10.1016/j.rmed.2019.04.023. Epub 2019 May 1.
9
Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias: What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification.基于 2013 年特发性间质性肺炎分类更新的现行非特异性间质性肺炎的计算机断层扫描表现：先前诊断的非特异性间质性肺炎排除在更新分类之外的特征是什么。
Jpn J Radiol. 2021 Jan;39(1):47-55. doi: 10.1007/s11604-020-01036-x. Epub 2020 Sep 1.
10
[Clinical analysis of different pathological patterns of nonspecific interstitial pneumonia].[非特异性间质性肺炎不同病理模式的临床分析]
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Nov;29(11):747-50.

引用本文的文献

1
C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice.C-X-C趋化因子受体4型抑制剂AMD3100减轻矽肺小鼠的肺部炎症和纤维化
J Inflamm Res. 2022 Oct 11;15:5827-5843. doi: 10.2147/JIR.S372751. eCollection 2022.
2
Discrimination between NSIP- and IPF-Derived Fibroblasts Based on Multi-Parameter Characterization of Their Growth, Morphology and Physic-Chemical Properties.基于生长、形态和物理化学特性的多参数特征对 NSIP 和 IPF 衍生成纤维细胞的鉴别。
Int J Mol Sci. 2022 Feb 15;23(4):2162. doi: 10.3390/ijms23042162.
3
Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players.

本文引用的文献

1
The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung.淋巴细胞在放疗引起的肺部晚期不良反应中的作用。
Front Immunol. 2016 Dec 14;7:591. doi: 10.3389/fimmu.2016.00591. eCollection 2016.
2
Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung.诱导性支气管相关淋巴组织：控制肺部炎症
Front Immunol. 2016 Jun 30;7:258. doi: 10.3389/fimmu.2016.00258. eCollection 2016.
3
Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis.
特发性肺纤维化：分子和细胞关键因素。
Int J Mol Sci. 2021 Aug 19;22(16):8952. doi: 10.3390/ijms22168952.
4
B Cell Dysregulation in Common Variable Immunodeficiency Interstitial Lung Disease.常见可变免疫缺陷性间质性肺疾病中的B细胞失调
Front Immunol. 2021 Feb 5;11:622114. doi: 10.3389/fimmu.2020.622114. eCollection 2020.
5
Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation.羊水间充质干细胞通过阻碍肺 B 细胞募集、滞留和成熟来减少肺纤维化。
Stem Cells Transl Med. 2020 Sep;9(9):1023-1035. doi: 10.1002/sctm.20-0068. Epub 2020 May 26.
IL-10 产生的调节性 B 细胞在二氧化硅诱导的肺炎症和纤维化过程中调节 T 辅助细胞免疫应答中的作用。
Sci Rep. 2016 Jun 29;6:28911. doi: 10.1038/srep28911.
4
Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis.特发性肺纤维化中的免疫炎症与疾病进展
PLoS One. 2016 May 9;11(5):e0154516. doi: 10.1371/journal.pone.0154516. eCollection 2016.
5
An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features.欧洲呼吸学会/美国胸科学会官方研究声明：具有自身免疫特征的间质性肺炎。
Eur Respir J. 2015 Oct;46(4):976-87. doi: 10.1183/13993003.00150-2015. Epub 2015 Jul 9.
6
B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.B细胞活化因子。重度慢性阻塞性肺疾病中淋巴滤泡的协调者。
Am J Respir Crit Care Med. 2015 Sep 15;192(6):695-705. doi: 10.1164/rccm.201501-0107OC.
7
Targeting B lymphocytes in progressive fibrosing mediastinitis.靶向进行性纤维性纵隔炎中的B淋巴细胞。
Am J Respir Crit Care Med. 2014 Nov 1;190(9):1069-71. doi: 10.1164/rccm.201407-1258LE.
8
Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus.利妥昔单抗治疗系统性硬化症相关间质性肺病合并系统性红斑狼疮的成功经验。
J Dermatol. 2014 May;41(5):418-20. doi: 10.1111/1346-8138.12461.
9
An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias.美国胸科学会/欧洲呼吸学会官方声明：特发性间质性肺炎的国际多学科分类的更新。
Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48. doi: 10.1164/rccm.201308-1483ST.
10
Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients.特发性肺纤维化患者血浆 B 淋巴细胞刺激因子与 B 细胞分化。
J Immunol. 2013 Sep 1;191(5):2089-95. doi: 10.4049/jimmunol.1203476. Epub 2013 Jul 19.