干扰素释放试验阳性患者中干扰素-γ受体 1 基因多态性的分布频率。
The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon- Release Assay-Positive Patients.
机构信息
Department of Clinical Laboratory, The Navy General Hospital, No. 6 Fucheng Road, Beijing 100037, China.
Department of Pathology, Donghua Hospital Affiliated to Zhongshan University, No. 1 Dongcheng Road, Dongguan, Guangdong 523110, China.
出版信息
Dis Markers. 2017;2017:4031671. doi: 10.1155/2017/4031671. Epub 2017 Oct 25.
Tuberculosis is caused by mycobacterium, a potentially fatal infectious bacterium. In recent years, TB cases increased in the whole world. WHO statistics data shows that the world's annual tuberculosis incidence was 8~10 million with about 3 million deaths. Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms. Here, we report the distribution frequency of IFNGR1 gene polymorphisms in 103 cases of IGA-negative patients and 100 cases of IGA-positive patients from China by sequencing the IFNGR1 proximal ~750 bp promoter region. We found a total of 5 types of site mutations: -611 (G/A), -56 (T/C), -255 (C/T), -359 (T/C), and -72 (C/T). The two main types of gene polymorphisms among the IGA-negative and IGA-positive groups were -611 (G/A), with mutation rates of 88.3% and 78.4%, respectively, and -56 (T/C), with mutation rates of 84.5% and 83.8%, respectively, which had no statistical significance, and there was no correlation with the incidence of tuberculosis.
结核病是由分枝杆菌引起的，分枝杆菌是一种潜在致命的传染性细菌。近年来，全世界的结核病病例有所增加。世界卫生组织的统计数据显示，全球每年结核病发病率为 800 万至 1000 万例，约有 300 万人死亡。几项研究表明，结核病的易感性可能与 IFNGR1 基因多态性有关。在这里，我们通过对中国 103 例 IGA 阴性患者和 100 例 IGA 阳性患者的 IFNGR1 近端~750bp 启动子区域进行测序，报告了 IFNGR1 基因多态性的分布频率。我们共发现了 5 种位点突变：-611（G/A）、-56（T/C）、-255（C/T）、-359（T/C）和-72（C/T）。在 IGA 阴性和 IGA 阳性两组中，两种主要的基因多态性是-611（G/A），突变率分别为 88.3%和 78.4%，以及-56（T/C），突变率分别为 84.5%和 83.8%，无统计学意义，与结核病的发病率也没有相关性。
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