-938C>A基因多态性与结核病易感性相关：一项初步研究。
The -938C>A Polymorphism in Is Associated with Susceptibility to Tuberculosis: A Pilot Study.
作者信息
Aggelou Kalliopi, Siapati Elena Konstantina, Gerogianni Irini, Daniil Zoe, Gourgoulianis Konstantinos, Ntanos Ioannis, Simantirakis Emmanouel, Zintzaras Elias, Mollaki Vassiliki, Vassilopoulos George
机构信息
Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece; 9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.
9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.
出版信息
Dis Markers. 2016;2016:4961086. doi: 10.1155/2016/4961086. Epub 2016 Dec 29.
. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. . The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 () gene polymorphisms in TB. . A total of 103 TB cases and 92 control subjects were genotyped for the 938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. . The -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, = 0.01). . The -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.
结核病（TB）是一种全球性的主要疾病，由结核分枝杆菌（MTB）感染引起。Toll样受体（TLR）途径在MTB的识别中起关键作用。本研究旨在调查髓样分化初级反应蛋白88（）基因多态性与结核病的关系。对103例结核病患者和92例对照受试者进行了938C>A（rs4988453）和1944C>G（rs4988457）多态性的基因分型。-938CA和-938AA基因型与结核病风险增加相关，比值比（OR）为5.71（95%置信区间[CIs]2.89-11.28，=0.01）。-938C>A基因多态性与结核病易感性增加相关，可作为筛选高危个体的标志物。
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