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2
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study.TLR9 和 MYD88 中的多态性和单倍型与霍奇金淋巴瘤的发展相关：候选基因关联研究。
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3
Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study.MyD88 多态性和单倍型与结节病的发展相关：候选基因关联研究。
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本文引用的文献

1
Epstein-Barr virus-induced gene 3 (EBI3) polymorphisms and expression are associated with susceptibility to pulmonary tuberculosis.爱泼斯坦-巴尔病毒诱导基因3（EBI3）多态性与表达和肺结核易感性相关。
Tuberculosis (Edinb). 2015 Jul;95(4):497-504. doi: 10.1016/j.tube.2015.03.009. Epub 2015 Apr 17.
2
Critical role of TRIF and MyD88 in Mycobacterium tuberculosis Hsp70-mediated activation of dendritic cells.TRIF和MyD88在结核分枝杆菌热休克蛋白70介导的树突状细胞激活中的关键作用
Cytokine. 2015 Feb;71(2):139-44. doi: 10.1016/j.cyto.2014.09.010. Epub 2014 Oct 29.
3
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4.对化脓性细菌有反应的转录模块的范围较窄，在携带 MYD88 或 IRAK4 功能丧失突变的患者中受损。
Nat Immunol. 2014 Dec;15(12):1134-42. doi: 10.1038/ni.3028. Epub 2014 Oct 26.
4
The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected].DNA 损伤调控自噬调节剂 DRAM1 通过 TLR-MYD88 将分枝杆菌识别与自噬防御联系起来[更正]。
Cell Host Microbe. 2014 Jun 11;15(6):753-67. doi: 10.1016/j.chom.2014.05.005.
5
MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.髓样细胞中的 MyD88 信号足以预防慢性分枝杆菌感染。
Eur J Immunol. 2014 May;44(5):1399-409. doi: 10.1002/eji.201344039. Epub 2014 Feb 13.
6
Functional TLR5 genetic variants affect human colorectal cancer survival.功能性 TLR5 基因变异影响人类结直肠癌的生存。
Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23.
7
The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis.MyD88 rs6853 和 TIRAP rs8177374 多态性位点与人类肺结核的耐药性相关。
Genes Immun. 2013 Dec;14(8):504-11. doi: 10.1038/gene.2013.48. Epub 2013 Sep 26.
8
Influence of Toll-like receptor gene polymorphisms to tuberculosis susceptibility in humans.Toll 样受体基因多态性对人类结核病易感性的影响。
Scand J Immunol. 2013 Sep;78(3):221-9. doi: 10.1111/sji.12066.
9
Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study.MyD88 多态性和单倍型与结节病的发展相关：候选基因关联研究。
Mol Biol Rep. 2013 Jul;40(7):4281-6. doi: 10.1007/s11033-013-2513-7. Epub 2013 May 11.
10
Global epidemiology of tuberculosis.全球结核病流行病学。
Semin Respir Crit Care Med. 2013 Feb;34(1):3-16. doi: 10.1055/s-0032-1333467. Epub 2013 Mar 4.

-938C>A基因多态性与结核病易感性相关：一项初步研究。

The -938C>A Polymorphism in Is Associated with Susceptibility to Tuberculosis: A Pilot Study.

作者信息

Aggelou Kalliopi, Siapati Elena Konstantina, Gerogianni Irini, Daniil Zoe, Gourgoulianis Konstantinos, Ntanos Ioannis, Simantirakis Emmanouel, Zintzaras Elias, Mollaki Vassiliki, Vassilopoulos George

机构信息

Department of Respiratory Medicine, University of Thessaly Medical School, Larissa, Greece; 9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.

9th Department for Chest Diseases, "Sotiria" Hospital, Athens, Greece.

出版信息

Dis Markers. 2016;2016:4961086. doi: 10.1155/2016/4961086. Epub 2016 Dec 29.

DOI:10.1155/2016/4961086
PMID:28127112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5227150/
Abstract

. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. . The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 () gene polymorphisms in TB. . A total of 103 TB cases and 92 control subjects were genotyped for the 938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. . The -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89-11.28, = 0.01). . The -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.

摘要

结核病（TB）是一种全球性的主要疾病，由结核分枝杆菌（MTB）感染引起。Toll样受体（TLR）途径在MTB的识别中起关键作用。本研究旨在调查髓样分化初级反应蛋白88（）基因多态性与结核病的关系。对103例结核病患者和92例对照受试者进行了938C>A（rs4988453）和1944C>G（rs4988457）多态性的基因分型。-938CA和-938AA基因型与结核病风险增加相关，比值比（OR）为5.71（95%置信区间[CIs]2.89-11.28，=0.01）。-938C>A基因多态性与结核病易感性增加相关，可作为筛选高危个体的标志物。