Schubert H D, Talbot C W, Federman J L
Retina Service, Wills Eye Hospital, Philadelphia, PA 19107.
Graefes Arch Clin Exp Ophthalmol. 1989;227(1):95-9. doi: 10.1007/BF02169833.
To examine the laser-tissue interactions for contact transscleral irradiation, argon and CW Nd:YAG light was delivered through a synthetic sapphire crystal which was held in direct conjunctival contact perpendicular to the peripheral retina. The threshold for retinal whitening was 0.5 J in the rabbit, 1.0-1.5 J in the monkey, and 1.0-4.0 J in human eyes. Histologic examination of the acute injury and at 2 days, 1, 3, 6, and 12 weeks, showed coagulative lesions centered around the pigmented layers in the rabbit. While severe chorioretinal disruption and hemorrhage did occur depending on species, energy level, and probe location, no scleral perforation was noted at any setting. These preliminary studies suggest that transscleral contact lasers may be used safely in clinical situations where selective ablation of the peripheral retina or pigmented tissues is the primary objective.
为了研究接触式经巩膜照射的激光与组织相互作用，氩激光和连续波钕：钇铝石榴石激光通过一块合成蓝宝石晶体传递，该晶体与周边视网膜垂直直接接触结膜。视网膜变白的阈值在兔眼中为0.5焦耳，在猴眼中为1.0 - 1.5焦耳，在人眼中为1.0 - 4.0焦耳。对急性损伤以及在2天、1周、3周、6周和12周时进行的组织学检查显示，兔眼中围绕色素层出现凝固性病变。虽然根据物种、能量水平和探头位置确实会发生严重的脉络膜视网膜破坏和出血，但在任何设置下均未发现巩膜穿孔。这些初步研究表明，经巩膜接触式激光可安全用于以选择性消融周边视网膜或色素组织为主要目标的临床情况。
