Del-Monte Jonathan, Bayard Sophie, Graziani Pierluigi, Gély-Nargeot Marie C
Social Psychology Laboratory EA 849, Aix-Marseille and Nîmes Universities, Nîmes, France.
Epsylon, Laboratory Dynamic of Human Abilities & Health Behaviors, Department of Sport Sciences, Psychology and Medicine, Montpellier University, Montpellier, France.
Front Behav Neurosci. 2017 Nov 21;11:230. doi: 10.3389/fnbeh.2017.00230. eCollection 2017.
Apathy is one of the most frequent non-motor manifestations in Parkinson's disease (PD) that can lead to a whole range of deleterious outcomes. In 2006, Levy and Dubois proposed a model that distinguishes three different apathy aetiologies in PD divided into three subtypes of disrupted processing: "emotional-affective," "cognitive," and "auto-activation." These three dimensions associated with dopamine depletion present in the pathology would lead to the emergence of apathy in PD. The aim of this mini-review was to describe and discuss studies that have explore links between apathy and the three subtypes of disrupted processing proposed by Levy and Dubois (2006) and as well as the links between these dimensions and dopamine depletion in Parkinson's disease. The lack of consensus regarding the emotional-affective correlates of apathy and the lack of evidence supporting the hypothesis of the auto-activation deficit, do not clearly confirm the validity of Levy and Dubois's model. Furthermore, the suggested association between dopaminergic depletion and apathy must also be clarified.
冷漠是帕金森病（PD）最常见的非运动症状之一，可导致一系列有害后果。2006年，利维（Levy）和迪布瓦（Dubois）提出了一个模型，该模型区分了PD中三种不同的冷漠病因，分为三种处理过程中断的亚型：“情感-情绪型”、“认知型”和“自我激活型”。与病理学中存在的多巴胺耗竭相关的这三个维度会导致PD中冷漠的出现。本综述的目的是描述和讨论探索冷漠与利维（Levy）和迪布瓦（Dubois）（2006年）提出的三种处理过程中断亚型之间联系的研究，以及这些维度与帕金森病中多巴胺耗竭之间的联系。关于冷漠的情感-情绪相关性缺乏共识，且缺乏支持自我激活缺陷假说的证据，这并未明确证实利维（Levy）和迪布瓦（Dubois）模型的有效性。此外，多巴胺能耗竭与冷漠之间的假定关联也必须加以阐明。
