Ang Yuen-Siang, Lockwood Patricia L, Kienast Annika, Plant Olivia, Drew Daniel, Slavkova Elitsa, Tamm Marin, Husain Masud
Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom.
Department of Experimental Psychology University of Oxford Oxford United Kingdom.
Ann Clin Transl Neurol. 2018 Aug 14;5(10):1286-1291. doi: 10.1002/acn3.626. eCollection 2018 Oct.
Apathy is highly prevalent in Parkinson's disease. New findings suggest the syndrome is multifaceted. Here, we investigate whether all aspects of apathy are equally affected in Parkinson's disease and whether different dimensions of apathy were associated with depression and anhedonia. On the Apathy Motivation Index, while behavioral apathy and social apathy were elevated, emotional motivation was relatively preserved in Parkinson's disease, although a few patients did show impaired emotional sensitivity. Behavioral and social, but emotional, apathy was associated with depression and anhedonia. These findings suggest aspects of motivation can be selectively impaired in Parkinson's disease and may have implications for guiding treatment.
冷漠在帕金森病中极为普遍。新的研究结果表明该综合征具有多方面特点。在此，我们探究帕金森病中冷漠的所有方面是否受到同等影响，以及冷漠的不同维度是否与抑郁和快感缺乏相关。在冷漠动机指数上，虽然行为冷漠和社交冷漠有所增加，但帕金森病患者的情感动机相对保留，不过少数患者确实表现出情感敏感性受损。行为和社交冷漠而非情感冷漠与抑郁和快感缺乏相关。这些发现表明帕金森病中动机的某些方面可能会被选择性损害，这可能对指导治疗具有启示意义。
