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Diabetes Mellitus and Alzheimer's Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models.

作者信息

Jia Jin-Jing, Zeng Xian-Si, Song Xin-Qiang, Zhang Peng-Peng, Chen Lei

机构信息

College of Life Sciences, Xinyang Normal University, Xinyang, China.

Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, China.

出版信息

Front Pharmacol. 2017 Nov 16;8:834. doi: 10.3389/fphar.2017.00834. eCollection 2017.

DOI:10.3389/fphar.2017.00834
PMID:29209211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5702501/
Abstract

Diabetes mellitus is considered as a risk factor of Alzheimer's disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7850/5702501/90a3c8df6a11/fphar-08-00834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7850/5702501/90a3c8df6a11/fphar-08-00834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7850/5702501/90a3c8df6a11/fphar-08-00834-g001.jpg

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[1]
Diabetes Mellitus and Alzheimer's Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models.

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[2]
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[5]
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[6]
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Curr Alzheimer Res. 2024

[2]
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[3]
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[4]
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FEBS Open Bio. 2022-12

[5]
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Mediators Inflamm. 2022

[6]
The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease.

Metab Brain Dis. 2022-12

[7]
Therapeutic Screening of Herbal Remedies for the Management of Diabetes.

Molecules. 2021-11-12

[8]
Is diabetes associated with increased pathological burden in Alzheimer's disease?

Alzheimers Dement (Amst). 2021-11-10

[9]
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Alzheimers Dement (N Y). 2021-3-31

[10]
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本文引用的文献

[1]
Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways.

Neuroscience. 2017-8-24

[2]
Impact of EGCG Supplementation on the Progression of Diabetic Nephropathy in Rats: An Insight into Fibrosis and Apoptosis.

J Agric Food Chem. 2017-9-13

[3]
Epigallocatechin-3-gallate protects against diabetic cardiomyopathy through modulating the cardiometabolic risk factors, oxidative stress, inflammation, cell death and fibrosis in streptozotocin-nicotinamide-induced diabetic rats.

Biomed Pharmacother. 2017-8-1

[4]
The role of melatonin in the onset and progression of type 3 diabetes.

Mol Brain. 2017-8-1

[5]
EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS.

FASEB J. 2017-11

[6]
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions.

Int J Mol Med. 2017-8

[7]
NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage.

Oxid Med Cell Longev. 2017-6-18

[8]
The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis.

J Biol Chem. 2017-9-1

[9]
Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration.

Synapse. 2017-10

[10]
The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.

Infect Agent Cancer. 2017-6-19

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