Department of Physiology, Jiaxing University Medical College, Jiaxing, China.
Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, China.
ASN Neuro. 2021 Jan-Dec;13:1759091421994351. doi: 10.1177/1759091421994351.
Alzheimer's disease (AD) is the most common neurodegenerative diseases. Increasing studies have demonstrated the critical importance for redox proteins mediating neuronal protection in models of AD. This review briefly describes some of the risk factors contributing to AD, specifically highlighting the important roles of oxidative stress in the pathology of AD. Then this article concisely introduces the dysregulation and functions of two main redox enzymes, peroxiredoxins and glutaredoxins, in AD models. This review emphasizes the neuroprotective role of the third redox enzyme thioredoxin (Trx), an important multifunctional protein regulating cellular redox status. This commentary not only summarizes the alterations of Trx expression in AD patients and models, but also reviews the potential effects and mechanisms of Trx, Trx-related molecules and Trx-inducing compounds against AD. In conclusion, Trx has a potential neuroprotection in AD and may be very promising for clinical therapy of AD in the future.
阿尔茨海默病（AD）是最常见的神经退行性疾病。越来越多的研究表明，氧化还原蛋白在 AD 模型中介导神经元保护具有重要意义。本文简要描述了一些导致 AD 的风险因素，特别强调了氧化应激在 AD 病理学中的重要作用。然后本文简要介绍了两种主要的氧化还原酶，过氧化物酶和谷氧还蛋白，在 AD 模型中的失调和功能。本文强调了第三氧化还原酶硫氧还蛋白（Trx）的神经保护作用，Trx 是一种调节细胞氧化还原状态的重要多功能蛋白。该评论不仅总结了 AD 患者和模型中 Trx 表达的改变，还综述了 Trx、Trx 相关分子和 Trx 诱导化合物对 AD 的潜在作用和机制。总之，Trx 在 AD 中具有潜在的神经保护作用，可能在未来的 AD 临床治疗中具有广阔的前景。
