[伴有MDM2扩增的梭形细胞骨硬化性骨病变]
[Spindle-cell osteosclerotic bone lesion with MDM2 amplification].
作者信息
Mogler C, Boxberg M, Knebel C, Weichert W, Wörtler K, Specht K
机构信息
Institut für Pathologie, Technische Universität München, Trogerstraße 18, 81675, München, Deutschland.
Klinik und Poliklinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar, München, Deutschland.
出版信息
Pathologe. 2018 Mar;39(2):186-190. doi: 10.1007/s00292-017-0394-6.
This case report presents an osteosclerotic bone lesion in a 49-year-old man with MDM2 amplification. The final diagnosis shows metastasis to the bones from stomach cancer. In primary bone tumours, the MDM2 amplifications observed have been described for many other tumour entities as well, and therefore do not exclude bone metastasis from a carcinoma.
本病例报告介绍了一名49岁患有MDM2基因扩增的男性患者的骨硬化性骨病变。最终诊断显示为胃癌骨转移。在原发性骨肿瘤中，观察到的MDM2基因扩增在许多其他肿瘤实体中也有描述，因此不能排除骨转移癌。
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