利用聚合物膜表面润湿性连续纯化活性药物成分。
Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability.
作者信息
Imbrogno Joseph, Rogers Luke, Thomas Dale A, Jensen Klavs F
机构信息
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Chem Commun (Camb). 2017 Dec 19;54(1):70-73. doi: 10.1039/c7cc08218e.
PMID:29210378
Abstract
Continuous processing of pharmaceuticals opens opportunities for continuous separation based on wettability of polymer membranes. Dual use of hydrophobic and hydrophilic membranes realize in-line liquid-liquid extraction in the synthesis of four essential APIs. A secondary membrane with opposite wetting characteristics proves critical to phase separation of aqueous-organic reaction streams.
摘要
药物的连续加工为基于聚合物膜润湿性的连续分离提供了机会。疏水膜和亲水膜的双重使用实现了四种基本活性药物成分合成中的在线液液萃取。具有相反润湿特性的二级膜被证明对水-有机反应流的相分离至关重要。
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