From the Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, China (QBZ, YZ, YL); and Department of Orthopaedics, The Second Hospital of Anhui Medical University, Hefei, China (YZ, HZZ).
Am J Phys Med Rehabil. 2018 May;97(5):357-363. doi: 10.1097/PHM.0000000000000873.
The aim of this study was to investigate the therapeutic effect of stretching combined with ultrashort wave on joint contracture and explore its possible mechanism.
Thirty-two rabbits underwent unilateral immobilization of a knee joint at full extension to cause joint contracture. At 6 wks after immobilization, the rabbits were randomly divided into the following four groups: natural recovery group, stretching treatment group, ultrashort wave treatment group, and combined treatment group. For comparison, eight control group animals of corresponding age were also examined. The effect of stretching and ultrashort wave treatment on joint contracture was assessed by measuring the joint range of motion, evaluating the collagen deposition of joint capsule and assessing the mRNA and protein levels for transforming growth factor β1 in the joint capsule.
The combined treatment group led to the best recovery of joint function. The combined treatment with stretching and ultrashort wave was more effective than stretching or ultrashort wave treatment alone against the synovial thickening of suprapatellar joint capsule, the collagen deposition of anterior joint capsule, and the elevated expression of transforming growth factor β1 in the joint capsule.
Stretching combined with ultrashort wave treatment was effective in improving joint range of motion, reducing the biomechanical, histological, and molecular manifestations of joint capsule fibrosis in a rabbit model of extending joint contracture.
本研究旨在探讨伸展联合超短波治疗对关节挛缩的疗效，并探讨其可能的机制。
32 只兔膝关节完全伸直固定以造成关节挛缩，固定 6 周后，随机分为自然恢复组、伸展治疗组、超短波治疗组和联合治疗组。同时设立 8 只相应年龄的对照组。通过测量关节活动度、评估关节囊胶原沉积以及检测关节囊内转化生长因子β1 的 mRNA 和蛋白水平，评估伸展和超短波治疗对关节挛缩的影响。
联合治疗组关节功能恢复最好。伸展联合超短波治疗在减轻髌上关节囊滑膜增厚、前关节囊胶原沉积以及关节囊内转化生长因子β1 表达升高方面，均优于单纯伸展或超短波治疗。
伸展联合超短波治疗可有效改善关节活动度，减轻兔伸直性关节挛缩模型中关节囊纤维化的生物力学、组织学和分子表现。
