Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Department of Histopathology, Manchester University NHS Foundation Trust, Manchester, UK.
J Clin Pathol. 2018 Mar;71(3):201-206. doi: 10.1136/jclinpath-2017-204863. Epub 2017 Dec 6.
To review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis.
We conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised.
Signet-ring cell carcinoma was represented in 7.61% of the 18 989 cases of oesophageal carcinoma reviewed in multiple studies. The presence of signet-ring cells conferred a worse prognosis and these tumours responded differently to conventional treatments as compared with typical adenocarcinoma. Little is known about the biological features of signet-ring cell adenocarcinoma of the oesophagus. Work in gastric lesions has identified potential targets for future treatments such as and genes. Categorisation of signet-ring cell carcinomas by the proportion of signet-ring cells within tumours differs among clinicians despite WHO criteria for classification. The current UK guidelines for histopathological reporting of oesophageal tumours do not emphasise the importance of identifying signet-ring cells.
The presence of signet-ring cells in oesophageal adenocarcinomas leads to poorer clinical outcomes. Current understanding of signet-ring cell biology in oesophageal cancer is limited.
回顾目前对印戒细胞型食管腺癌的认识，包括预后的证据。
我们对九个医疗保健文献数据库进行了文献检索，以查找详细描述食管印戒细胞腺癌生物学和临床结果的文章。分析并以书面文字和表格形式详细阐述了印戒细胞形态的影响。总结了目前对食管印戒细胞腺癌生物学的认识。
在多项研究中对 18989 例食管癌病例的回顾中，印戒细胞癌占 7.61%。印戒细胞的存在预示着预后更差，与典型腺癌相比，这些肿瘤对常规治疗的反应不同。目前对食管印戒细胞腺癌的生物学特征知之甚少。在胃病变中的研究已经确定了未来治疗的潜在靶点，如 和 基因。尽管有世界卫生组织的分类标准，但临床医生对肿瘤内印戒细胞比例的印戒细胞癌分类存在差异。目前英国对食管肿瘤组织病理学报告的指南并没有强调识别印戒细胞的重要性。
食管腺癌中存在印戒细胞会导致更差的临床结果。目前对食管癌中印戒细胞生物学的认识有限。
