Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Diabetes. 2018 Feb;67(2):248-255. doi: 10.2337/db17-1156. Epub 2017 Dec 6.
Little is known about the genetic influence on BMI trajectory throughout adulthood. We created a genetic risk score (GRS) comprising 97 adult BMI-associated variants among 9,971 women and 6,405 men of European ancestry. Serial measures of BMI were assessed from 18 (women) or 21 (men) years to 85 years of age. We also examined BMI change in early (from 18 or 21 to 45 years of age), middle (from 45 to 65 years of age), and late adulthood (from 65 to 80 years of age). GRS was positively associated with BMI across all ages, with stronger associations in women than in men. The associations increased from early to middle adulthood, peaked at 45 years of age in men and at 60 years of age in women (0.91 and 1.35 kg/m per 10-allele increment, respectively) and subsequently declined in late adulthood. For women, each 10-allele increment in the GRS was associated with an average BMI gain of 0.54 kg/m in early adulthood, whereas no statistically significant association was found for BMI change in middle or late adulthood or for BMI change in any life period in men. Our findings indicate that genetic predisposition exerts a persistent effect on adiposity throughout adult life and increases early adulthood weight gain in women.
关于遗传因素对整个成年期 BMI 轨迹的影响，我们知之甚少。我们创建了一个遗传风险评分（GRS），该评分由 9791 名女性和 6405 名欧洲血统的男性中与成人 BMI 相关的 97 个变体组成。从 18 岁（女性）或 21 岁（男性）到 85 岁，对 BMI 进行了连续测量。我们还检查了早期（从 18 或 21 岁到 45 岁）、中期（从 45 岁到 65 岁）和晚期（从 65 岁到 80 岁）的 BMI 变化。GRS 与所有年龄段的 BMI 呈正相关，女性的相关性强于男性。这种关联从早期到中年逐渐增加，在男性中 45 岁和女性中 60 岁达到峰值（分别为每增加 10 个等位基因 0.91 和 1.35 公斤/米），随后在晚年下降。对于女性，GRS 中每增加 10 个等位基因，平均 BMI 就会增加 0.54 公斤/米，而在中年或晚年或男性任何生命阶段的 BMI 变化中均未发现统计学上的显著关联。我们的研究结果表明，遗传易感性在整个成年期对肥胖持续产生影响，并增加了女性的早期成年体重增加。
