衰老与胃泌素分泌：大鼠血清及胃窦部胃泌素浓度的变化

Aging and gastrin production: changes in serum and antral gastrin concentrations in the rat.

作者信息

Holt P R, Yeh K Y

机构信息

Division of Gastroenterology, St. Luke's Hospital Center, New York, NY 10025.

出版信息

J Gerontol. 1989 Mar;44(2):M62-5. doi: 10.1093/geronj/44.2.m62.

DOI:10.1093/geronj/44.2.m62

PMID:2921471

Abstract

Serum gastrin concentration and antral gastrin content were measured in 4-5- and 26-28-mo rats under fed conditions, after 3 days of starvation, and after 1 day of refeeding after starvation, to determine whether gastrin homeostasis is altered during aging. Gastric weight was 29% greater, but antral weight and DNA were less in the older rats. Serum gastrin fell during starvation and rose during refeeding in both groups, but it was lower in aging rats only during refeeding. Antral gastrin content in older animals was 60% of that in young rats. Starvation reduced antral gastrin only in the young, whereas refeeding lowered antral gastrin in the older animals. We conclude that, in aging rats, the relationship of serum and antral gastrin is altered during changes in food intake.

摘要

在进食条件下、饥饿3天后以及饥饿后再喂食1天后，对4至5月龄和26至28月龄的大鼠测定血清胃泌素浓度和胃窦胃泌素含量，以确定衰老过程中胃泌素稳态是否发生改变。老年大鼠的胃重量增加了29%，但胃窦重量和DNA含量较低。两组大鼠在饥饿期间血清胃泌素均下降，再喂食期间均上升，但仅在再喂食期间，老年大鼠的血清胃泌素较低。老年动物的胃窦胃泌素含量是年轻大鼠的60%。饥饿仅使年轻大鼠的胃窦胃泌素减少，而再喂食则使老年动物的胃窦胃泌素降低。我们得出结论，在衰老大鼠中，食物摄入变化期间血清和胃窦胃泌素的关系发生了改变。