人类巨噬细胞中的 RSV 感染促进细菌共感染期间 CXCL10/IP-10 的表达。
RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection.
机构信息
Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69007 Lyon, France.
Virologie et Pathologie Humaine-VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69008 Lyon, France.
出版信息
Int J Mol Sci. 2017 Dec 7;18(12):2654. doi: 10.3390/ijms18122654.
Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus/ () co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with . Our results suggest that contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs.
呼吸道合胞病毒（RSV）是急性下呼吸道感染的主要病原体，是全球导致婴幼儿死亡的主要原因。病毒/细菌混合感染与呼吸道炎症性疾病的严重程度有关，但潜在机制仍不清楚。我们之前使用人单核细胞来源的巨噬细胞（MDM）模型研究了流感病毒/（）合并感染时介导免疫反应的细胞内机制。在这里，我们建立并鉴定了一个类似的 MDM 模型，以研究 RSV 感染和与（）合并感染的不同情况。我们的结果表明，在人 MDM 中，（）有助于 RSV 感染诱导的 CXCL10/IP-10 表达更快和可能更高水平。
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