Olsen I, Jonsen J
Scand J Dent Res. 1979 Apr;87(2):123-8.
The distribution patterns of 90Sr in five littermate, 8-day-old Wistar rats were studied by whole body autoradiography. Rats were killed 15 min, 1, 4, 24, and 72 h after a single intraperitoneal injection of the isotope. Immediately after administration, 90Sr was distributed throughout most of the soft tissues of the body. The soft tissue deposits had practically disappeared after 4 h. In the hard tissues of the body 90Sr accumulated up to 24-72 h. Fifteen minutes after injection the uptake of 90Sr in the enamel of the teeth was highest in the occlusal and incisal regions. 90Sr gradually accumulated throughout the enamel and after 72 h its distribution in this layer was fairly uniform. Immediately after injection a narrow zone of radioactivity appeared in the dentin near the pulp. This zone broadened with time towards the dentinoenamel junction and included the entire dentin layer 72 h after injection. Initially, the uptake of 90Sr was higher in the dentin thatn in the enamel, particularly in the cervical areas of the crown. This difference became less apparent with time. There was good correlation between the uptake in teeth and bones, supporting the use of teeth as indicators of the 90Sr body burden.
通过全身放射自显影研究了五只同窝8日龄Wistar大鼠体内90锶的分布模式。在单次腹腔注射该同位素后15分钟、1小时、4小时、24小时和72小时处死大鼠。给药后，90锶立即分布于身体的大部分软组织中。4小时后软组织中的沉积物几乎消失。在身体的硬组织中，90锶在24至72小时内积累。注射后15分钟，牙齿釉质在咬合面和切缘区域对90锶的摄取最高。90锶逐渐在整个釉质中积累，72小时后其在该层的分布相当均匀。注射后，牙髓附近的牙本质中立即出现一条狭窄的放射性带。随着时间的推移，该带向牙釉质牙本质界扩展，注射72小时后包括整个牙本质层。最初，牙本质中90锶的摄取高于釉质，尤其是在牙冠的颈部区域。随着时间的推移，这种差异变得不那么明显。牙齿和骨骼中的摄取之间存在良好的相关性，支持将牙齿用作90锶身体负荷指标。
