Eppley B L, Doucet M J, Winkelmann T, Delfino J J
Division of Oral-Maxillofacial Surgery, St John's Mercy Medical Center, St Louis, MO 63141.
J Oral Maxillofac Surg. 1989 Mar;47(3):257-76. doi: 10.1016/0278-2391(89)90229-2.
A study was designed to evaluate the ability of the rabbit mandibular nerve to regenerate when exposed to crush and resection injuries, as well as to determine how differently sized resection injuries healed when repaired with either autogenous grafts or laminin-lined collagen tubulization. The nerve demonstrated a regenerative capacity over a 1-cm defect, with morphology and function that approximated normals, but could not span a 2-cm gap defect unaided. Crush injuries produced findings that were inferior to both those in normal nerves and in those with resections. In 1-cm defects, both grafting and tubular repairs produced similar results, with substantial recovery of neural function after 16 weeks. In 2-cm defects, autogenous grafting was superior to tubulization by both morphologic and functional assessment. Replacement of the lateral cortex of the mandible after nerve repair was shown to be unnecessary. The implications of these findings as they relate to nerve injury and repair in humans is discussed.
一项研究旨在评估兔下颌神经在遭受挤压和切除损伤时的再生能力，以及确定当用自体移植物或层粘连蛋白包被的胶原微管修复不同大小的切除损伤时愈合情况有何不同。该神经在1厘米的缺损上表现出再生能力，其形态和功能接近正常，但无法独自跨越2厘米的间隙缺损。挤压伤产生的结果比正常神经和切除伤的结果都要差。在1厘米的缺损中，移植和微管修复产生了相似的结果，16周后神经功能有显著恢复。在2厘米的缺损中，通过形态学和功能评估，自体移植优于微管修复。结果表明，神经修复后无需替换下颌骨的外侧皮质。讨论了这些发现对人类神经损伤和修复的意义。
