Murao T, Tanahashi T, Matsumura Y
Dept. of Pathology, Okayama City Hospital.
Gan No Rinsho. 1989 Jan;35(1):114-9.
The immunohistochemical and electron microscopic characteristics of a vesical carcinoma with a sarcomatous change in a 90-year-old man are described. Keratin was strongly positive in the carcinomatous region and was also identified in the sarcomatous region. CEA was present only in the carcinomatous region. Both the carcinomatous and sarcomatous regions were negative for S 100 protein, myoglobin, lysozyme, and desmin. Electron microscopically, a few tumor cells with tonofilaments were observed in the sarcomatous region. Many tumor cells in the sarcomatous region had no characteristic structures suggestive of epithelial or mesenchymal origin. However, transitional types of tumor cells, between the epithelial cells and the cells with neither epithelial nor mesenchymal differentiation, were noticed. Therefore, this suggested that the sarcomatous region was a site of immature epithelial cell proliferation.
本文描述了一名90岁男性膀胱癌细胞肉瘤样变的免疫组化和电镜特征。角蛋白在癌性区域呈强阳性，在肉瘤样区域也有表达。癌胚抗原仅存在于癌性区域。癌性和肉瘤样区域的S100蛋白、肌红蛋白、溶菌酶和结蛋白均为阴性。电镜下，在肉瘤样区域观察到少数含有张力丝的肿瘤细胞。肉瘤样区域的许多肿瘤细胞没有提示上皮或间叶起源的特征性结构。然而，注意到上皮细胞与既无上皮也无间叶分化的细胞之间存在过渡型肿瘤细胞。因此，这表明肉瘤样区域是未成熟上皮细胞增殖的部位。
