Horsdal Henriette T, Wimberley Theresa, Köhler-Forsberg Ole, Baandrup Lone, Gasse Christiane
National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus BSS, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative Psychiatric Research, Aarhus, Denmark.
Early Interv Psychiatry. 2018 Dec;12(6):1198-1202. doi: 10.1111/eip.12522. Epub 2017 Dec 8.
Several factors such as age, gender, urbanicity and clinical treatment setting have been associated with treatment-resistant schizophrenia (TRS). We examined the association between the Global Assessment of Functioning (social Functioning [GAF-F]) score at first schizophrenia diagnosis and TRS and explored whether level of functioning could partially explain the known associations.
A nationwide population-based cohort study among individuals, who had a GAF-F score at first schizophrenia diagnosis. We used adjusted Cox regression analysis to calculate hazard ratios (HRs).
Among 3252 individuals, severe functional impairment (GAF-F ≤ 30) was associated with TRS within 2 years after diagnosis (adjusted HR = 1.38 [95% confidence interval: 1.03-1.87). GAF-F had virtually no impact on the associations between investigated known risk factors and TRS.
GAF-F was independently associated with TRS. Consideration of a global functioning score may help clinicians to detect treatment resistance earlier among individuals with schizophrenia.
年龄、性别、城市化程度和临床治疗环境等多种因素与难治性精神分裂症（TRS）相关。我们研究了首次精神分裂症诊断时的总体功能评估（社会功能[GAF-F]）得分与TRS之间的关联，并探讨功能水平是否能部分解释已知的关联。
对首次精神分裂症诊断时有GAF-F得分的个体进行一项基于全国人群的队列研究。我们使用调整后的Cox回归分析来计算风险比（HRs）。
在3252名个体中，严重功能损害（GAF-F≤30）与诊断后2年内的TRS相关（调整后的HR = 1.38 [95%置信区间：1.03 - 1.87]）。GAF-F对所研究的已知风险因素与TRS之间的关联几乎没有影响。
GAF-F与TRS独立相关。考虑总体功能得分可能有助于临床医生在精神分裂症患者中更早地发现治疗抵抗。
