Ali Murtaza, Firoz Chelapram K, Jabir Nasimudeen R, Rehan Mohd, Khan Mohd S, Tabrez Shams
Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Endocr Metab Immune Disord Drug Targets. 2018 Feb 13;18(2):110-123. doi: 10.2174/1871530318666171207145003.
Systemic lupus erythematosus (SLE) is a diverse autoimmune disorder, evoked in response to self-immune system that leads to immune complex depositions and organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental factors have been suggested that could influence its pathogenesis.
The modulation in B- and T- cell responses and genetic variations could lead to abnormal lymphocyte functions and the production of antibodies against the indigenous proteins and the immune complex depositions.
The present review highlights the various causatives of SLE, particularly the genetic alteration in B- and T-cell-related proteins. We have also delineated some of the available therapeutic strategies for the treatment of SLE.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，由自身免疫系统引发，导致免疫复合物沉积和器官损伤。SLE发病的确切机制仍不清楚，但已有研究表明某些遗传和环境因素可能影响其发病机制。
B细胞和T细胞反应的调节以及基因变异可能导致淋巴细胞功能异常，产生针对自身蛋白质的抗体以及免疫复合物沉积。
本综述重点介绍了SLE的各种病因，尤其是B细胞和T细胞相关蛋白的基因改变。我们还阐述了一些现有的SLE治疗策略。
