Institut für Organische und Biomolekulare Chemie, Universität Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany.
Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2459-2463. doi: 10.1002/anie.201711599. Epub 2018 Jan 17.
A catalytic regime for the direct phosphatation of simple, non-polarized alkenes has been devised that is based on using ordinary, non-activated phosphoric acid diesters as the phosphate source and O as the terminal oxidant. The title method enables the direct and highly economic construction of a diverse range of allylic phosphate esters. From a conceptual viewpoint, the aerobic phosphatation is entirely complementary to traditional methods for phosphate ester formation, which predominantly rely on the use of prefunctionalized or preactivated reactants, such as alcohols and phosphoryl halides. The title transformation is enabled by the interplay of a photoredox and a selenium π-acid catalyst and involves a sequence of single-electron-transfer processes.
已经设计出一种用于简单非极化烯烃直接膦酸化的催化体系，该体系基于使用普通非活化磷酸二酯作为磷酸源和 O 作为末端氧化剂。该方法能够直接且经济高效地构建各种烯丙基磷酸酯。从概念上讲，有氧膦酸化与传统的磷酸酯形成方法完全互补，后者主要依赖于使用预官能化或预活化的反应物，如醇和磷卤化物。该转化是通过光氧化还原和硒 π-酸催化剂的相互作用来实现的，涉及一系列单电子转移过程。
