Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala Science Park, 75185, Uppsala, Sweden.
Östervåla Primary Health Care Centre, Åbygränd 2, 74046, Östervåla, Sweden.
Obes Surg. 2018 Jun;28(6):1526-1531. doi: 10.1007/s11695-017-3035-5.
Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP).
One hundred twenty-four morbidly obese non-diabetic patients were evaluated before (baseline) and 12 months after (follow-up) RYGBP.
Body mass index (BMI) was reduced from 43.5 kg/m (baseline) to 31.1 kg/m (follow-up), and p < 0.001 and weight declined from 126.2 to 89.0 kg. PCs decreased from 303 × 10 to 260 × 10/l, p < 0.001. GGT was reduced from 0.63 to 0.38 μkat/l, p < 0.001. ALT decreased from 0.69 to 0.59 μkat/l, p = 0.006. CRP was lowered from 7.3 to 5.4 mg/l p < 0.001 and ferritin from 106 to 84 μg/l p < 0.001. The alterations in PCs correlated with the changes in CRP (r = 0.38, p = 0.001), BMI (r = 0.25, p = 0.012), weight (r = 0.24, p = 0.015) and inversely correlated with ferritin (r = 21, p = 0.036).
PCs, GGT and ALT (markers for NAFLD), and CRP and ferritin (markers for inflammation) decreased in morbidly obese after RYGBP. The decrease in PCs correlated with alterations in CRP, BMI, weight and ferritin. The lowering of liver enzymes may reflect a lowered liver fat content and decreased general inflammation.
肥胖与慢性炎症、肝脂肪变性以及γ-谷氨酰转移酶（GGT）和丙氨酸氨基转移酶（ALT）等肝酶升高有关，这些都是非酒精性脂肪性肝病（NAFLD）和肝脂肪含量的标志物。血小板计数（PCs）升高是反映 NAFLD 炎症和纤维化程度的生物标志物。我们研究了 Roux-en-Y 胃旁路术（RYGBP）后 PCs、GGT、ALT、C 反应蛋白（CRP）和铁蛋白的变化。
124 例肥胖非糖尿病患者在 RYGBP 术前（基线）和术后 12 个月（随访）进行评估。
体重指数（BMI）从 43.5kg/m2（基线）降至 31.1kg/m2（随访），p<0.001，体重从 126.2kg 降至 89.0kg。PCs 从 303×10 降至 260×10/l，p<0.001。GGT 从 0.63 降至 0.38μkat/l，p<0.001。ALT 从 0.69 降至 0.59μkat/l，p=0.006。CRP 从 7.3 降至 5.4mg/l，p<0.001，铁蛋白从 106 降至 84μg/l，p<0.001。PCs 的变化与 CRP（r=0.38，p=0.001）、BMI（r=0.25，p=0.012）、体重（r=0.24，p=0.015）的变化相关，与铁蛋白呈负相关（r=0.21，p=0.036）。
RYGBP 后肥胖患者的 PCs、GGT 和 ALT（NAFLD 标志物）以及 CRP 和铁蛋白（炎症标志物）降低。PCs 的降低与 CRP、BMI、体重和铁蛋白的变化相关。肝酶的降低可能反映肝脂肪含量降低和全身炎症减轻。
