Department of General Surgery, Numune Teaching and Research Hospital, 06100 Ankara, Turkey.
Obes Surg. 2010 May;20(5):610-5. doi: 10.1007/s11695-009-0061-y. Epub 2010 Jan 12.
There are differences in the levels of inflammation mediators, lipids, and formed elements of the blood in morbidly obese patients compared with individuals of normal weight. In the current study, the change in these parameters was determined in patients who achieved weight loss by undergoing laparoscopic adjustable gastric banding (LAGB) by comparing preoperative, and early (3 months) and late (12 months) postoperative values.
The body mass index (BMI), weight, blood pressure, and waist circumference of 72 patients treated by LAGB procedures between September 2006 and February 2009 were measured and recorded. Pre- and postoperative 3- and 12-month C-reactive protein (CRP), immunoglobulin (Ig) G, IgA, IgM, fibrinogen (Fbg), complement components C3 and C4, total cholesterol, triglycerides, low-density lipoprotein-C and high-density lipoprotein-C levels, and leukocyte, neutrophil, lymphocyte, and platelet counts were also measured. Results were presented as mean +/- SD. The preoperative values were compared with the 3- and 12-month values. A p value < 0.05 was considered statistically significant.
BMI, weight, blood pressure, and waist circumference measurements were reduced at 3 and 12 months postoperatively compared with preoperative values (p < 0.05). Among the inflammatory mediators, IgG, IgM, and Fbg were reduced to near-normal values, beginning in the early postoperative period (p < 0.05). There was no significant reduction parallel to weight loss with respect to CRP, C3, C4, and IgA values at 3 months postoperatively (p > 0.05). However, the 12-month values of these parameters were significantly reduced (p < 0.05).
Morbid obesity leads to significant changes in the levels of inflammation mediators. While there is a significant reduction in some of these mediators accompanying slight weight loss in the early period following an LAGB procedure, significant changes occur in other mediators in the late period when there is a larger amount of weight loss.
病态肥胖患者的炎症介质、脂质和血液有形成分的水平与体重正常的个体存在差异。在本研究中，通过比较腹腔镜可调胃束带术（LAGB）前后的术前、术后早期（3 个月）和晚期（12 个月）值，确定了这些参数在接受 LAGB 治疗的患者中体重减轻后的变化。
测量并记录了 72 例接受 LAGB 治疗的患者的体重指数（BMI）、体重、血压和腰围。测量并记录术前、术后 3 个月和 12 个月时 C 反应蛋白（CRP）、免疫球蛋白（Ig）G、IgA、IgM、纤维蛋白原（Fbg）、补体成分 C3 和 C4、总胆固醇、甘油三酯、低密度脂蛋白-C 和高密度脂蛋白-C 水平以及白细胞、中性粒细胞、淋巴细胞和血小板计数。结果以平均值±标准差表示。将术前值与术后 3 个月和 12 个月的值进行比较。p 值<0.05 被认为具有统计学意义。
术后 3 个月和 12 个月时，BMI、体重、血压和腰围均较术前降低（p<0.05）。在炎症介质中，术后早期 IgG、IgM 和 Fbg 降至接近正常水平（p<0.05）。术后 3 个月时，CRP、C3、C4 和 IgA 值与体重减轻无显著平行降低（p>0.05）。然而，12 个月时这些参数的数值显著降低（p<0.05）。
病态肥胖导致炎症介质水平发生显著变化。虽然在 LAGB 手术后早期伴随轻微体重减轻会导致其中一些介质显著减少，但在晚期随着体重减轻量增加时，其他介质会发生显著变化。
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