Department of Internal Medicine, Medical Intensive Care Unit, University of Tübingen, Tübingen, Germany; Department of Internal Medicine, Endocrinology und Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.
Department of Internal Medicine, Endocrinology und Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.
Blood Rev. 2018 May;32(3):225-234. doi: 10.1016/j.blre.2017.11.005. Epub 2017 Nov 29.
Castleman's disease (CD) is a rare lymphoproliferative disorder with its distinct unicentric (uCD) and multicentric (mCD) entities. The present work aimed at characterizing CD in more detail. From the 775 articles found by a PubMed search, 1133 cases were extracted. Two own cases were included. UCD was identified in 719 (42% males) and mCD in 416 (63% males) cases. Age in uCD was 34±17 and in mCD 48±18years. The hyaline-vascular type predominated in uCD and the plasma cell type in mCD. Clinical symptoms were more common in mCD. The head and neck region was most frequently affected in uCD and the axillary region in mCD. Prevalence of human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) positivity was higher in mCD. In CT scans, high contrast enhancement and calcifications were more frequent in uCD (all p<0.0001). The two forms of CD not only differ markedly in their clinical, laboratory and imaging findings, but also in treatment response and prognosis.
卡斯尔曼病 (CD) 是一种罕见的淋巴组织增生性疾病，具有独特的局灶性 (uCD) 和多灶性 (mCD) 实体。本研究旨在更详细地描述 CD。通过 PubMed 搜索发现了 775 篇文章，从中提取了 1133 例病例。还包括了两个自己的病例。719 例为 uCD（42%为男性），416 例为 mCD（63%为男性）。uCD 的年龄为 34±17 岁，mCD 的年龄为 48±18 岁。uCD 以透明血管型为主，mCD 以浆细胞型为主。mCD 更常见临床症状。uCD 最常累及头颈部，mCD 最常累及腋窝。mCD 中人类免疫缺陷病毒 (HIV) 和人类疱疹病毒-8 (HHV-8) 阳性率较高。在 CT 扫描中，uCD 更常出现高对比度增强和钙化（均 p<0.0001）。这两种形式的 CD 在临床表现、实验室和影像学表现以及治疗反应和预后方面差异显著。
