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定制钛三维打印椎间融合器治疗骨质疏松性骨折相关脊柱畸形

Custom-Made Titanium 3-Dimensional Printed Interbody Cages for Treatment of Osteoporotic Fracture-Related Spinal Deformity.

作者信息

Siu Timothy L, Rogers Jeffrey M, Lin Kainu, Thompson Robert, Owbridge Mark

机构信息

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, New South Wales, Australia.

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, New South Wales, Australia.

出版信息

World Neurosurg. 2018 Mar;111:1-5. doi: 10.1016/j.wneu.2017.11.160. Epub 2017 Dec 6.

Abstract

BACKGROUND

Advances in minimally invasive interbody fusion have greatly enhanced surgeons' capability to correct adult spinal deformity with reduced morbidity. However, the feasibility of such approaches is limited in patients with previous osteoporotic fractures as the resultant vertebral deformity renders the end plate geometry incongruous with conventional interbody implants. Current 3-dimensional (3D) printing technology offers a novel solution by fabricating custom-made implants tailored to individual anatomy. We present the results of a patient with osteoporotic lumbar fractures treated by such technology.

CASE DESCRIPTION

A 74-year-old woman, with previous osteoporotic fractures at L2 and L3 resulting in concave deformity of the end plates, presented with intractable radiculopathy secondary to lateral recess and foraminal stenosis (L2-3 and L3-4). A minimally invasive lateral lumbar interbody fusion at L2-3 and L3-4 was considered favorable, but due to the associated vertebral collapse, off-the-shelf implants were not compatible with patient anatomy. In silico simulation based on preoperative computed tomography (CT) imaging was thus conducted to design customized cages to cater for the depressed recipient end plates and vertebral loss. The design was converted to implantable titanium cages through 3D additive manufacturing. At surgery, a tight fit between the implants and the targeted disk space was achieved. Postoperative CT scan confirmed excellent implant-end plate matching and restoration of lost disk space. The patient began to ambulate from postoperative day 1 and at 6-month follow-up resolution of radicular symptoms and CT evidence of interbody fusion were recorded.

CONCLUSIONS

3D-printed custom-made interbody cages can help overcome the difficulties in deformity correction secondary to osteoporotic fractures.

摘要

背景

微创椎体间融合技术的进展极大地提高了外科医生矫正成人脊柱畸形并降低发病率的能力。然而,对于既往有骨质疏松性骨折的患者,此类方法的可行性有限,因为由此产生的椎体畸形使终板几何形状与传统椎体间植入物不一致。当前的三维(3D)打印技术通过制造适合个体解剖结构的定制植入物提供了一种新的解决方案。我们展示了一名采用该技术治疗的骨质疏松性腰椎骨折患者的治疗结果。

病例描述

一名74岁女性,既往L2和L3有骨质疏松性骨折,导致终板凹陷畸形,因侧隐窝和椎间孔狭窄(L2 - 3和L3 - 4)出现顽固性神经根病。L2 - 3和L3 - 4节段进行微创腰椎外侧椎体间融合术被认为是合适的,但由于相关的椎体塌陷,现成的植入物与患者解剖结构不匹配。因此,基于术前计算机断层扫描(CT)成像进行了计算机模拟,以设计定制的椎间融合器,以适应凹陷的受体终板和椎体骨质丢失。通过3D增材制造将设计转换为可植入的钛制椎间融合器。手术中,植入物与目标椎间盘间隙紧密贴合。术后CT扫描证实植入物与终板匹配良好,丢失的椎间盘间隙得到恢复。患者术后第1天即可行走,6个月随访时记录到神经根症状消失及椎间融合的CT证据。

结论

3D打印定制椎间融合器有助于克服骨质疏松性骨折继发的畸形矫正困难。

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