Department of Oral & Maxillofacial Surgery, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.
J Craniomaxillofac Surg. 2018 Feb;46(2):288-292. doi: 10.1016/j.jcms.2017.11.015. Epub 2017 Nov 22.
Mandibular advancement devices are commonly used in the treatment of patients with mild to moderate obstructive sleep apnea (OSA). Designed to maintain the mandible in forced protrusion while being worn, mandibular advancement devices (MADs) are intended to increase the upper airway during sleep, thereby reducing OSA symptoms. Depending on the extent of mandibular protrusion, side effects including temporomandibular joint dysfunction are frequently reported. These are likely to reduce overall treatment success by affecting therapeutic adherence.
To investigate the biomechanical effects of an MAD on the temporomandibular joints, we used a biomechanical model of the human masticatory system. Alterations to the model were applied to mimic the effects of a titratable duoblock MAD. The extent of mandibular protrusion was simulated up to 10 mm in steps of 1 mm. Compression and shear stresses on the temporomandibular structures were predicted during an open-close maneuver and in neutral position.
As the extent of mandibular advancement increased, the mandibular condyle migrated anteriorly until passing the articular tubercle. Stress on the temporomandibular joint structures did not considerably increase in rest whatever the extent of mandibular advancement. However, closure of the jaw required extra muscle force as mandibular advancement increased.
Results from this study suggest that temporomandibular dysfunction following MAD wearing might be related to altered muscle dynamics rather than changes due to increased stress in the temporomandibular joint itself.
下颌前伸装置常用于治疗轻至中度阻塞性睡眠呼吸暂停(OSA)患者。设计为在佩戴时保持下颌强制前伸,下颌前伸装置(MADs)旨在增加睡眠时的上气道,从而减少 OSA 症状。根据下颌前伸的程度,经常报告包括颞下颌关节功能障碍在内的副作用。这些副作用可能会通过影响治疗依从性来降低整体治疗成功率。
为了研究 MAD 对颞下颌关节的生物力学影响,我们使用了人类咀嚼系统的生物力学模型。对模型进行了修改,以模拟可滴定双块 MAD 的效果。模拟了 10mm 以内 1mm 步长的下颌前伸程度。在开闭口运动和中立位预测了颞下颌结构的压缩和剪切应力。
随着下颌前伸程度的增加,下颌髁突向前迁移,直到越过关节结节。无论下颌前伸程度如何,在休息时,颞下颌关节结构的应力都没有明显增加。然而,随着下颌前伸的增加,闭合下颌需要额外的肌肉力量。
这项研究的结果表明,MAD 佩戴后颞下颌功能障碍可能与肌肉动力学改变有关,而不是与颞下颌关节本身的应力增加有关。