Shiino A, Harada K, Handa J
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
Surg Neurol. 1989 Mar;31(3):203-8. doi: 10.1016/0090-3019(89)90118-3.
Using 74 male rats, anatomical variations of branching of the proximal segment of the middle cerebral artery were studied. In 36 rats (28 Sprague-Dawley rats and eight spontaneously hypertensive rats), the middle cerebral artery and/or its branches were occluded at various sites. Occlusion of the middle cerebral artery at the lateral border of the olfactory tract with or without simultaneous ligation of the ipsilateral common carotid artery rarely caused cerebral infarction in Sprague-Dawley rats. Occlusion of the olfactory branch in addition to the trunk of the middle cerebral artery caused large infarction of the pallium in five of eight Sprague-Dawley rats. Occlusion of the middle cerebral artery at the medial border of the olfactory tract caused infarction in the pallium and/or basal ganglia in five of six rats, and neurologic deficits were severe and persistent. Occlusion of the middle cerebral artery at the lateral border of the olfactory tract in spontaneously hypertensive rats caused large infarction with severe neurologic deficits in all eight animals. Possible factors responsible for such diverse differences and the relative value of each group as an experimental model of focal cerebral ischemia in rats were discussed.
使用74只雄性大鼠，研究了大脑中动脉近端分支的解剖变异。在36只大鼠（28只斯普拉格-道利大鼠和8只自发性高血压大鼠）中，大脑中动脉及其分支在不同部位被阻断。在斯普拉格-道利大鼠中，在嗅束外侧缘阻断大脑中动脉，无论是否同时结扎同侧颈总动脉，很少引起脑梗死。除大脑中动脉主干外，阻断嗅支导致8只斯普拉格-道利大鼠中有5只大脑皮层大面积梗死。在嗅束内侧缘阻断大脑中动脉，导致6只大鼠中有5只大脑皮层和/或基底神经节梗死，神经功能缺损严重且持续存在。在自发性高血压大鼠中，在嗅束外侧缘阻断大脑中动脉，导致所有8只动物出现大面积梗死和严重神经功能缺损。讨论了造成这种差异的可能因素以及每组作为大鼠局灶性脑缺血实验模型的相对价值。
