Department of General Surgery, Zhongshan Hospital, Institute of General Surgery & Shanghai Medical College, Fudan University, Shanghai 200032, PR China.
Future Oncol. 2018 Jan;14(2):165-175. doi: 10.2217/fon-2017-0380. Epub 2017 Dec 11.
To identify the risk factors for overall survival (OS) of pancreatic ductal adenocarcinoma patients with no distant metastasis, and formulate a novel nomogram for prognostic prediction.
PATIENTS & METHODS: Data were obtained from Surveillance, Epidemiology, and End Results database of pancreatic ductal adenocarcinoma patients with no distant metastasis as the primary cohort, and 127 patients at our institution were enrolled as the validation cohort. The prognostic nomogram integrating all independent risk factors for predicting OS was established to achieve superior discriminatory ability.
The constructed nomogram showed excellent performance and superior predictive accuracy for OS according to the concordance index and calibration curve.
One more advanced and accurate predictive model will be obtained to assist in risk stratification via the constructed nomogram.
确定无远处转移的胰腺导管腺癌患者总生存期（OS）的危险因素，并制定新的列线图进行预后预测。
本研究数据来源于无远处转移的胰腺导管腺癌患者的监测、流行病学和最终结果数据库，作为主要队列，并纳入了本机构的 127 名患者作为验证队列。建立了一个整合所有独立的 OS 预测风险因素的预后列线图，以实现更好的区分能力。
根据一致性指数和校准曲线，构建的列线图显示出了优异的 OS 预测性能和准确性。
通过构建的列线图，可以获得一个更先进、更准确的预测模型，以协助风险分层。
