肠球菌属粪肠球菌的毒力进化，一种适应医院环境的机会性病原体。
Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen.
机构信息
Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia.
Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3010, Australia; Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia.
出版信息
Curr Opin Microbiol. 2018 Feb;41:76-82. doi: 10.1016/j.mib.2017.11.030. Epub 2017 Dec 9.
Enterococci are long-standing members of the human microbiome and they are also widely distributed in nature. However, with the surge of antibiotic-resistance in recent decades, two enterococcal species (Enterococcus faecalis and Enterococcus faecium) have emerged to become significant nosocomial pathogens, acquiring extensive antibiotic resistance. In this review, we summarize what is known about the evolution of virulence in E. faecium, highlighting a specific clone of E. faecium called ST796 that has emerged recently and spread globally.
肠球菌是人类微生物组的长期成员，它们也广泛分布于自然界中。然而，近几十年来，随着抗生素耐药性的激增，两种肠球菌（粪肠球菌和屎肠球菌）已经成为重要的医院病原体，获得了广泛的抗生素耐药性。在这篇综述中，我们总结了肠球菌毒力进化的已知情况，重点介绍了最近出现并在全球范围内传播的一种称为 ST796 的特定屎肠球菌克隆。
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