An Shujuan, Gong Xia, Zhao Long, Jian Jinli, Guo Yuancheng, Yang Xiaoxiao, Sun Hongjia, Li Yang, Liu Bei
The First Clinical Medical College, Lanzhou University, Lanzhou, China.
Department of Medical Laboratory, The First Hospital of Lanzhou University, Lanzhou, China.
Front Microbiol. 2025 Apr 1;16:1559033. doi: 10.3389/fmicb.2025.1559033. eCollection 2025.
The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including , , , and , as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients. In contrast, and , especially , were significantly enriched. Further investigation indicated that could serve as a potential intestinal marker, showing a strong negative correlation with the levels of acetic and butyric acid. Importantly, assays aimed at identifying AML demonstrated that , butyric acid, and acetatic acid exhibited excellent predictive effectiveness. Colonizing from patients were isolated for pathogen investigation, which revealed that these bacteria possess several strong virulence factors and multiple drug-resistance gene characteristics. Therefore, we speculate that the increase of may contribute to the development and progression of AML.
本研究的目的是确定新诊断的急性髓系白血病（AML）患者的肠道微生物群和代谢产物是否表现出特定的特征性改变，以及这些变化是否可作为预测该疾病的潜在生物标志物。值得注意的是，AML患者的肠道微生物群和代谢产物在初次诊断时表现出显著的结构和数量改变。发现包括[具体细菌名称1]、[具体细菌名称2]、[具体细菌名称3]和[具体细菌名称4]在内的有益细菌以及丁酸和乙酸在新诊断的AML患者中显著减少。相比之下，[具体细菌名称5]和[具体细菌名称6]，尤其是[具体细菌名称6]显著富集。进一步研究表明，[具体细菌名称6]可作为一种潜在的肠道标志物，与乙酸和丁酸水平呈强烈负相关。重要的是，旨在识别AML的检测表明，[具体细菌名称6]、丁酸和乙酸表现出优异的预测效力。从患者中分离出[具体细菌名称6]进行病原体调查，结果显示这些细菌具有几种强大的毒力因子和多重耐药基因特征。因此，我们推测[具体细菌名称6]的增加可能有助于AML的发生和发展。
