Ma Shanshan, Guo Junbin, Lu Danlei, Zhu Lixia, Zhou Meng, Zhou De, Li Li, Zhu Jingjing, Yang Xiudi, Zheng Yanlong, Ye Xiujin, Xie Wanzhuo
Department of Hematology, the First Affiliated Hospital of Medical School of Zhejiang University, Zhejiang, Hangzhou, China.
Department of Hematology and Oncology, Wenling City First People's Hospital, Zhejiang, Wenling, China.
Oncotarget. 2017 Oct 23;8(58):98533-98541. doi: 10.18632/oncotarget.21963. eCollection 2017 Nov 17.
Lymph node enlargement is a common presentation and has a possibility of malignancy like lymphoma that requires early diagnosis. This study aims to analyze the clinical characteristics of these patients and finds out useful predictors of malignant diseases. We retrospectively investigated 81 patients with lymph node enlargement between July 2, 2014 and May 17, 2016. The characteristics and laboratory findings were evaluated combining with the final diagnosis. The diagnoses were malignancy in 51 patients and benign lymphadenopathy in 30 patients. Increased beta2-microglobulin (B2M) ( = 0.012) was found to be associated with malignant diseases, and level of 3699.5 μg/L was used as a cut-off value to differentiate the malignancies from benign diseases, offering 63.4% sensitivity and 87.0% specificity. Immunoglobulin G (IgG) ( = 0.038) levels were significantly lower in malignant group, whose receiver operating characteristic curve showed that level of 1121.5 mg/dl had sensitivity and specificity as 58.5% and 82.6%. Moreover, through analysis of cytokines, we found interleukin-10 (IL-10) levels were elevated in malignant group compared with benign group. Serum B2M and IgG levels were concluded to be useful parameters for predicting malignancies. Besides, increased IL-10 levels indicated a higher risk of malignancy in some way.
淋巴结肿大是一种常见症状，有可能是淋巴瘤等恶性疾病，需要早期诊断。本研究旨在分析这些患者的临床特征，并找出恶性疾病的有用预测指标。我们回顾性调查了2014年7月2日至2016年5月17日期间81例淋巴结肿大患者。结合最终诊断对其特征和实验室检查结果进行评估。诊断结果为51例恶性肿瘤患者和30例良性淋巴结病患者。发现β2-微球蛋白（B2M）升高（=0.012）与恶性疾病相关，以3699.5μg/L作为区分恶性肿瘤与良性疾病的临界值，灵敏度为63.4%，特异性为87.0%。恶性组免疫球蛋白G（IgG）（=0.038）水平显著降低，其受试者工作特征曲线显示，1121.5mg/dl水平的灵敏度和特异性分别为58.5%和82.6%。此外，通过细胞因子分析，我们发现恶性组白细胞介素-10（IL-10）水平高于良性组。血清B2M和IgG水平被认为是预测恶性肿瘤的有用参数。此外，IL-10水平升高在某种程度上表明恶性肿瘤风险较高。
