直肠复合性神经内分泌肿瘤和腺癌
Composite neuroendocrine tumor and adenocarcinoma of the rectum.
作者信息
Kanno-Okada Hiromi, Mitsuhashi Tomoko, Mabe Katsuhiro, Shimoda Tadakazu, Matsuno Yoshihiro
机构信息
Department of Surgical Pathology, Hokkaido University Hospital, North 14, West 5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan.
Department of Gastroenterology, Hakodate National Hospital, Kawahara-cho 18-16, Hakodate, Hokkaido, 041-8512, Japan.
出版信息
Diagn Pathol. 2017 Dec 11;12(1):85. doi: 10.1186/s13000-017-0674-8.
BACKGROUND
Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) Grade 1 and adenocarcinoma are exceedingly rare.
CASE PRESENTATION
A 64-year-old male presented after testing positive for fecal occult blood at a medical check-up. A biopsy demonstrated the presence of a NET and endoscopic submucosal dissection was undertaken. Histologic examination revealed that a well differentiated tubular adenocarcinoma was present in addition to the NET. Furthermore, histological transition between the two tumors was evident. Accordingly, this case was considered to be a composite tumor comprising NET and adenocarcinoma.
CONCLUSION
Composite tumors consisting of NET Grade 1 and adenocarcinoma are exceedingly rare, and only a few examples have been reported hitherto.
背景
虽然有时会遇到显示神经内分泌分化的腺癌或与高级别神经内分泌癌（NEC）混合的腺癌，但由1级神经内分泌肿瘤（NET）和腺癌组成的复合肿瘤极为罕见。
病例介绍
一名64岁男性在体检时粪便潜血检测呈阳性后前来就诊。活检显示存在NET，并进行了内镜黏膜下剥离术。组织学检查显示，除NET外，还存在高分化管状腺癌。此外，两种肿瘤之间的组织学转变明显。因此，该病例被认为是由NET和腺癌组成的复合肿瘤。
结论
由1级NET和腺癌组成的复合肿瘤极为罕见，迄今为止仅有少数病例报道。
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