Kubo Kimitoshi, Kimura Noriko, Mabe Katsuhiro, Nishimura Yusuke, Kato Mototsugu
Department of Gastroenterology, National Hospital Organization Hakodate Hospital, Japan.
Department of Pathology, National Hospital Organization Hakodate Hospital, Japan.
Intern Med. 2018 Oct 15;57(20):2951-2955. doi: 10.2169/internalmedicine.0842-18. Epub 2018 May 18.
The endoscopic and pathological features of early gastric mixed adenoneuroendocrine carcinoma (MANEC), as well as its carcinogenesis, remain largely unclear. Screening esophagogastroduodenoscopy was performed on an 80-year-old man, revealing 3 superficial elevated lesions. Endoscopic submucosal dissection (ESD) was performed, and the patient was diagnosed with intramucosal gastric cancer comprising mixed adenocarcinoma and neuroendocrine tumor, well-differentiated adenocarcinoma and well-differentiated adenocarcinoma, with negative margins. To our knowledge, this is the first report describing the endoscopic and pathological findings of synchronous triple gastric cancer incorporating mixed adenocarcinoma and neuroendocrine tumor completely resected with ESD.
早期胃混合性腺神经内分泌癌（MANEC）的内镜及病理特征及其致癌机制在很大程度上仍不清楚。对一名80岁男性进行了食管胃十二指肠镜筛查，发现3处浅表隆起性病变。进行了内镜下黏膜剥离术（ESD），患者被诊断为黏膜内胃癌，包括混合性腺癌和神经内分泌肿瘤、高分化腺癌和高分化腺癌，切缘阴性。据我们所知，这是第一份描述经ESD完整切除的包含混合性腺癌和神经内分泌肿瘤的同步三发性胃癌的内镜及病理表现的报告。
