Boland Karen, Nguyen Geoffrey C
Dr Boland is an inflammatory bowel disease fellow and Dr Nguyen is a clinician scientist at the Mount Sinai Hospital IBD Centre in Toronto, Canada. Dr Nguyen is also an associate professor of medicine at the University of Toronto in Toronto, Canada.
Gastroenterol Hepatol (N Y). 2017 Nov;13(11):671-677.
Microscopic colitis (MC) is a chronic inflammatory bowel disease characterized by chronic watery diarrhea and diagnosed with the histologic hallmarks of disease despite a macroscopically normal large bowel. Although 2 distinct disease phenotypes exist, their clinical presentations and epidemiologic characteristics have overlapping features. This article summarizes evidence regarding the pathogenesis of MC, mechanisms of diarrhea in this cohort, and associations with medications. In addition, currently recommended and novel therapeutic approaches to achieving remission in this patient population are reviewed.
显微镜下结肠炎（MC）是一种慢性炎症性肠病，其特征为慢性水样腹泻，尽管大肠在宏观上正常，但仍可根据疾病的组织学特征进行诊断。虽然存在两种不同的疾病表型，但其临床表现和流行病学特征具有重叠性。本文总结了关于MC发病机制、该队列中腹泻机制以及与药物关联的证据。此外，还综述了目前推荐的以及在该患者群体中实现缓解的新治疗方法。
