炎症、ROS 和诱变。

Inflammation, ROS, and Mutagenesis.

机构信息

Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

出版信息

Cancer Cell. 2017 Dec 11;32(6):727-729. doi: 10.1016/j.ccell.2017.11.015.

DOI:10.1016/j.ccell.2017.11.015

PMID:29232551

Abstract

It has long been hypothesized that reactive oxygen species (ROS) are responsible for the association between chronic inflammatory diseases and increased tumor incidence. In this issue of Cancer Cell, Canli et al. now demonstrate that amplified ROS production specifically by myeloid cells is sufficient to promote intestinal mutagenesis.

摘要

长期以来，人们一直假设活性氧（ROS）是慢性炎症性疾病与肿瘤发生率增加之间关联的罪魁祸首。在本期《癌细胞》杂志中，Canli 等人现在证明，骨髓细胞中 ROS 的产生增加足以促进肠道致突变。