Li Zhiyan, Lu Yanjun, Wang Lulu, Shi Liuyi, Wang Tao
Department of Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China
Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China.
Nanoscale Adv. 2025 Apr 16. doi: 10.1039/d5na00321k.
Reactive oxygen species (ROS) play a double-edged role in gastric cancer (GC). Higher levels of ROS in tumor cells compared to normal cells facilitate tumor progression. Once ROS concentrations rise rapidly to toxic levels, they cause GC cell death, which is instead beneficial for GC treatment. Based on these functions, nano-delivery systems taking the therapeutic advantages of ROS have been widely employed in tumor therapy in recent years, overcoming the drawbacks of conventional drug delivery techniques, such as non-specific systemic effects. In this review, the precise impacts of ROS on GC have been detailed, along with ROS-based nanomedicine therapeutic schemes. These strategies mainly focused on the use of excess ROS in the tumor microenvironment for controlled drug release and a substantial enhancement of ROS concentrations for tumor killing. The challenges and opportunities for the advancement of these anticancer therapies are also emphasized.
活性氧（ROS）在胃癌（GC）中发挥着双刃剑作用。与正常细胞相比，肿瘤细胞中较高水平的ROS促进肿瘤进展。一旦ROS浓度迅速上升至毒性水平，它们会导致GC细胞死亡，这反而有利于GC治疗。基于这些功能，近年来利用ROS治疗优势的纳米递送系统已广泛应用于肿瘤治疗，克服了传统药物递送技术的缺点，如非特异性全身效应。在这篇综述中，详细阐述了ROS对GC的确切影响以及基于ROS的纳米医学治疗方案。这些策略主要集中在利用肿瘤微环境中过量的ROS进行可控药物释放以及大幅提高ROS浓度以杀死肿瘤。还强调了这些抗癌疗法进展所面临的挑战和机遇。
