Imaging the glutamate receptor subtypes-Much achieved, and still much to do.

作者信息

Gruber Stefan, Ametamey Simon M

机构信息

Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, Zurich CH-8093, Switzerland.

出版信息

Drug Discov Today Technol. 2017 Nov;25:27-36. doi: 10.1016/j.ddtec.2017.10.006. Epub 2017 Nov 8.

DOI:10.1016/j.ddtec.2017.10.006

PMID:29233264

Abstract

Functional imaging of glutamate receptors using PET imaging modality can be used to study numerous CNS disorders and also to select appropriate doses of clinically relevant glutamate-receptor-targeting candidate drugs. Great strides have been made in developing PET imaging probes for the non-invasive detection of glutamate receptors in the brain. This review highlights recent progress made towards the development of glutamatergic PET imaging agents. Focus is placed on PET imaging probes that have been labelled with either carbon-11 or fluorine-18.

摘要