Makvandi Mehran, Sellmyer Mark A, Mach Robert H
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Drug Discov Today Technol. 2017 Nov;25:37-43. doi: 10.1016/j.ddtec.2017.11.001. Epub 2017 Nov 22.
Cancer and neurodegeneration represent two opposite ends of the biological spectrum but contain many common biological mechanisms. Two such mechanisms include the elevated levels of oxidative stress and DNA damage. In this brief review, we describe current approaches for imaging these biological pathways with the molecular imaging technique, Positron Emission Tomography (PET), and the potential of PET imaging studies to measure the efficacy of anticancer drugs and strategies for delaying the progression of neurodegenerative disorders.
癌症和神经退行性疾病代表了生物谱的两个相反端点，但包含许多共同的生物学机制。其中两个机制包括氧化应激水平升高和DNA损伤。在这篇简短的综述中，我们描述了利用分子成像技术正电子发射断层扫描（PET）对这些生物学途径进行成像的当前方法，以及PET成像研究在测量抗癌药物疗效和延缓神经退行性疾病进展策略方面的潜力。
