一项评估3D打印分子建模工具在药学专业学生教育中的价值的试点研究。

A pilot study assessing the value of 3D printed molecular modelling tools for pharmacy student education.

作者信息

Hall Susan, Grant Gary, Arora Devinder, Karaksha Abdullah, McFarland Amelia, Lohning Anna, Anoopkumar-Dukie Shailendra

机构信息

School of Pharmacy, Griffith University, Gold Coast Campus, QLD 4222, Australia; Australia and Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

School of Medicine, Griffith University, Gold Coast Campus, QLD 4222, Australia; Australia and Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

出版信息

Curr Pharm Teach Learn. 2017 Jul;9(4):723-728. doi: 10.1016/j.cptl.2017.03.029. Epub 2017 May 31.

DOI:10.1016/j.cptl.2017.03.029

PMID:29233449

Abstract

BACKGROUND AND PURPOSE

Medicinal chemistry and pharmacology are difficult topics to both teach and learn given the complex nature of drug mechanisms and drug-receptor interactions. This highlights the need for innovative teaching methods to deliver this information to students. One such method is through three-dimensional (3D) printing of enzymes and ligands in the teaching of molecular modelling concepts relating to drug-receptor and enzyme interactions be ligands. This type of printing has been shown to be beneficial in several educational settings; however, to our knowledge, its effectiveness in pharmacy, medicinal chemistry and pharmacology learning and teaching is largely unknown. Therefore, the aim of this study was to evaluate pharmacy student perceptions and the educational benefits of 3D printed molecules in molecular modelling with regards to engagement and learning outcomes when used in a drug-target interaction topic.

EDUCATIONAL ACTIVITY AND SETTING

This aim was achieved through administering students a short questionnaire designed to evaluate their engagement and learning outcomes with students also free to provide comments.

FINDINGS

This study found that nearly all (>90%) students found the activity was useful in improving both student engagement and learning outcomes.

DISCUSSION AND SUMMARY

In conclusion, 3D printing may provide an alternative learning activity to help pharmacy students understand the drug-target interaction.

摘要

背景与目的

鉴于药物作用机制和药物-受体相互作用的复杂性，药物化学和药理学是既难教又难学的课题。这凸显了采用创新教学方法向学生传授这些知识的必要性。其中一种方法是在与药物-受体和酶相互作用相关的分子建模概念教学中，通过三维（3D）打印酶和配体。这种打印方式已被证明在多种教育环境中都有益处；然而，据我们所知，其在药学、药物化学和药理学学习与教学中的有效性在很大程度上尚不清楚。因此，本研究的目的是评估药学专业学生对3D打印分子在药物靶点相互作用主题的分子建模中的看法，以及其在参与度和学习成果方面的教育益处。