Department of Orthopaedics, Rush University Medical Center, Chicago, Illinois.
Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois.
J Arthroplasty. 2018 Apr;33(4):1040-1044.e1. doi: 10.1016/j.arth.2017.11.013. Epub 2017 Nov 13.
Adductor canal blocks (ACBs) are an alternative to femoral nerve blocks that minimize lower extremity weakness. However, it is unclear whether this block will provide analgesia that is equivalent to techniques, such as epidural analgesia. The purpose of this randomized controlled trial was to compare continuous ACBs with epidural analgesia for primary total knee arthroplasty.
Following institutional review board approval, 145 patients were randomized to 1 of 3 groups: combined spinal-epidural (CSE), spinal + continuous ACB (CACB), or general + CACB. Epidural analgesia was used postoperatively in the CSE group, and an adductor canal catheter was used in the CACB groups. Power analysis determined that 84 patients per group were needed to demonstrate a 35% increase in ambulation with an alpha of 0.05 at a power of 90%.
At interim analysis, 13 patients were removed for protocol deviations, leaving 45 in CSE, 41 in spinal + CACB and 46 in general + CACB groups. Patient demographics were similar in all comparisons suggesting appropriate randomization. Patients in the CACB groups walked further on postoperative day 1, 2, and 3 (P = .02). Mean daily pain scores were lower in the CACB groups (4.1 CSE, 3.0 spinal + CACB, 3.4 general + CACB, P = .009). There was no significant difference in total opioid consumption between groups (158 morphine equivalents CSE, 149 spinal + CACB, and 172 general + CACB). More patients reported being "very satisfied" in CACB groups (68% general + CACB, 63% spinal + CACB, and 36% CSE; P = .001).
Continuous adductor analgesia provides superior ambulation, lower pain scores, faster discharge, and greater patient satisfaction when compared to epidural analgesia for primary total knee arthroplasty.
收肌管阻滞(ACB)是一种替代股神经阻滞的方法,可最大限度地减少下肢无力。然而,目前尚不清楚这种阻滞是否能提供与硬膜外镇痛等技术相当的镇痛效果。本随机对照试验的目的是比较连续收肌管阻滞与硬膜外镇痛在初次全膝关节置换术中的效果。
在机构审查委员会批准后,将 145 名患者随机分为 3 组:联合脊髓-硬膜外(CSE)、脊髓+连续收肌管阻滞(CACB)或全身麻醉+CACB。CSE 组术后使用硬膜外镇痛,CACB 组使用收肌管导管。通过功效分析,确定每组需要 84 例患者,以达到 90%的功效和 0.05 的α值,才能显示出 35%的步行能力增加。
在中期分析中,因违反方案,13 例患者被剔除,最终每组纳入 45 例 CSE 组、41 例脊髓+CACB 组和 46 例全身麻醉+CACB 组。所有比较中患者的人口统计学特征相似,提示分组恰当。CACB 组患者在术后第 1、2、3 天的步行距离更远(P =.02)。CACB 组的平均每日疼痛评分较低(CSE 组为 4.1,脊髓+CACB 组为 3.0,全身麻醉+CACB 组为 3.4,P =.009)。3 组患者的阿片类药物总消耗量无显著差异(CSE 组为 158 吗啡当量,脊髓+CACB 组为 149 吗啡当量,全身麻醉+CACB 组为 172 吗啡当量)。更多的患者在 CACB 组中报告“非常满意”(全身麻醉+CACB 组为 68%,脊髓+CACB 组为 63%,CSE 组为 36%;P =.001)。
与硬膜外镇痛相比,连续收肌管阻滞可为初次全膝关节置换术提供更好的活动能力、更低的疼痛评分、更快的出院速度和更高的患者满意度。