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1
Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles.在一项随机的 I 期研究中,重复给予 dapiroizumab pegol 具有良好的耐受性,并伴有全身性红斑狼疮疾病活动的几个综合指标的改善,以及全血转录组谱的变化。
Ann Rheum Dis. 2017 Nov;76(11):1837-1844. doi: 10.1136/annrheumdis-2017-211388. Epub 2017 Aug 5.
2
Antigen-specific immunotherapies in rheumatic diseases.风湿性疾病的抗原特异性免疫治疗。
Nat Rev Rheumatol. 2017 Sep;13(9):525-537. doi: 10.1038/nrrheum.2017.107. Epub 2017 Jul 13.
3
Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double-Blind, Placebo-Controlled Trials.依鲁替尼治疗中重度活动系统性红斑狼疮的疗效和安全性:两项 III 期随机、双盲、安慰剂对照临床试验结果。
Arthritis Rheumatol. 2017 Feb;69(2):362-375. doi: 10.1002/art.39856.
4
Remission in systemic lupus erythematosus: durable remission is rare.系统性红斑狼疮的缓解:持久缓解罕见。
Ann Rheum Dis. 2017 Mar;76(3):547-553. doi: 10.1136/annrheumdis-2016-209489. Epub 2016 Aug 24.
5
Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.低剂量白细胞介素-2 治疗可选择性调节系统性红斑狼疮患者的 CD4(+) T 细胞亚群。
Nat Med. 2016 Sep;22(9):991-3. doi: 10.1038/nm.4148. Epub 2016 Aug 8.
6
Systemic lupus erythematosus.系统性红斑狼疮。
Nat Rev Dis Primers. 2016 Jun 16;2:16039. doi: 10.1038/nrdp.2016.39.
7
Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study.脐带间充质干细胞移植治疗系统性红斑狼疮的长期安全性:一项 6 年随访研究。
Clin Exp Med. 2017 Aug;17(3):333-340. doi: 10.1007/s10238-016-0427-0. Epub 2016 Jun 7.
8
Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study.西法莫单抗,一种抗干扰素-α单克隆抗体,用于中重度系统性红斑狼疮:一项随机、双盲、安慰剂对照研究。
Ann Rheum Dis. 2016 Nov;75(11):1909-1916. doi: 10.1136/annrheumdis-2015-208562. Epub 2016 Mar 23.
9
Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody.抗干扰素-α受体1抗体阿尼鲁单抗拮抗活性的分子基础。
MAbs. 2015;7(2):428-39. doi: 10.1080/19420862.2015.1007810.
10
Treat-to-target in systemic lupus erythematosus: recommendations from an international task force.靶向治疗系统性红斑狼疮:国际工作组的建议。
Ann Rheum Dis. 2014 Jun;73(6):958-67. doi: 10.1136/annrheumdis-2013-205139. Epub 2014 Apr 16.

An era of biological treatment in systemic lupus erythematosus.

作者信息

He Jing, Li Zhanguo

机构信息

Department of Rheumatology & Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.

出版信息

Clin Rheumatol. 2018 Jan;37(1):1-3. doi: 10.1007/s10067-017-3933-x. Epub 2017 Dec 12.

DOI:10.1007/s10067-017-3933-x
PMID:29234909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5754454/
Abstract
摘要