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New insights into HEATR1 functions.
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Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells.
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The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
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Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
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Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content.
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The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.
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PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells.
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Distinct roles of MDMX in the regulation of p53 response to ribosomal stress.
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Proteomic-based stemness score measures oncogenic dedifferentiation and enables the identification of druggable targets.
Cell Genom. 2025 Jun 11;5(6):100851. doi: 10.1016/j.xgen.2025.100851. Epub 2025 Apr 17.
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HEATR1 modulates cell survival in non-small cell lung cancer via activation of the p53/PUMA signaling pathway.
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A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype.
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2
Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.
Mol Cell. 2017 Jul 6;67(1):55-70.e4. doi: 10.1016/j.molcel.2017.06.005. Epub 2017 Jun 29.
3
Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma.
J Immunol Res. 2014;2014:131494. doi: 10.1155/2014/131494. Epub 2014 Jul 9.
4
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
Biochim Biophys Acta. 2014 Jun;1842(6):817-30. doi: 10.1016/j.bbadis.2013.08.014. Epub 2013 Oct 26.
6
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation.
RNA. 2007 Sep;13(9):1516-27. doi: 10.1261/rna.609807. Epub 2007 Jul 24.
7
Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system.
J Biol Chem. 2006 May 12;281(19):13309-13316. doi: 10.1074/jbc.M601892200. Epub 2006 Mar 10.

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