Blackburn J R, Phillips A G, Jakubovic A, Fibiger H C
University of British Columbia, Vancouver, Canada.
Behav Neurosci. 1989 Feb;103(1):15-23. doi: 10.1037//0735-7044.103.1.15.
Changes in the activity of dopamine-containing systems in relation to preparatory and consummatory feeding responses were investigated. In Experiment 1 rats were conditioned to associate food delivery with the presentation of a conditional stimulus (CS+). When sacrificed after exposure to the CS+ alone on a test trial, the ratio of the dopamine metabolite 3,4-dihydroxyphenylacetic acid to dopamine (DOPAC/DA ratio) was increased significantly in the nucleus accumbens. A similar trend in the ratio of homovanillic acid to dopamine (HVA/DA ratio) was also observed. Similar increases were observed in the striatum, but these were not statistically significant. In contrast, no increases were observed in the DOPAC/DA ratio or the HVA/DA ratio in either brain region when rats were permitted to consume an unsignaled meal for 7 min. These findings suggest that activation of dopamine terminals in the nucleus accumbens occurs during the anticipation of a meal, at which times the rat is engaged in preparatory feeding behaviors, but does not accompany the performance of short bouts of consummatory feeding behavior.
研究了与进食前和进食时反应相关的含多巴胺系统的活性变化。在实验1中，大鼠被训练将食物递送与条件刺激（CS+）的呈现联系起来。在测试试验中仅暴露于CS+后处死大鼠时，伏隔核中多巴胺代谢物3,4-二羟基苯乙酸与多巴胺的比率（DOPAC/DA比率）显著增加。在高香草酸与多巴胺的比率（HVA/DA比率）中也观察到类似趋势。在纹状体中也观察到类似的增加，但这些增加没有统计学意义。相比之下，当大鼠被允许无信号进食7分钟时，在任一脑区的DOPAC/DA比率或HVA/DA比率中均未观察到增加。这些发现表明，在预期进食期间，伏隔核中的多巴胺终末会被激活，此时大鼠参与进食前的行为，但不伴随短暂的进食行为。
