语义整合过程中与年龄相关的适应性大脑反应降低与灰质减少有关。
Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction.
作者信息
Zhu Zude, Yang Fengjun, Li Dongning, Zhou Lianjun, Liu Ying, Zhang Ying, Chen Xuezhi
机构信息
School of Linguistics Sciences and Arts, and Collaborative Innovation Center for Language Competence, Jiangsu Normal University, Xuzhou, China.
Ningcheng Central Hospital, Chifeng, China.
出版信息
PLoS One. 2017 Dec 13;12(12):e0189462. doi: 10.1371/journal.pone.0189462. eCollection 2017.
While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25-75 year-old adults read sentences with high cloze (HC) and low cloze (LC) probability while functional magnetic resonance imaging was conducted. Significant age-related reduction of cloze effect (LC vs. HC) was found in several regions, especially the left middle frontal gyrus (MFG) and right inferior frontal gyrus (IFG), which play an important role in semantic integration. Moreover, when accounting for global gray matter volume reduction, the age-cloze correlation in the left MFG and right IFG was absent. The results suggest that brain structural atrophy may disrupt brain response in aging brains, which then show less brain engagement in semantic integration.
虽然衰老与知识增加有关，但它也与语义整合能力下降有关。为了研究语义整合过程中大脑激活的变化，对48名年龄在25至75岁之间的成年人进行了功能性磁共振成像扫描，让他们阅读具有高填充率（HC）和低填充率（LC）可能性的句子。在几个区域发现了与年龄相关的显著填充效应降低（LC与HC相比），特别是在左额中回（MFG）和右额下回（IFG），这两个区域在语义整合中起着重要作用。此外，当考虑到全脑灰质体积减少时，左MFG和右IFG中的年龄-填充率相关性消失。结果表明，大脑结构萎缩可能会破坏衰老大脑中的大脑反应，进而在语义整合中表现出较少的大脑参与。
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