CDH1 启动子甲基化在宫颈癌患者中的研究：一项系统的荟萃分析与试验序贯分析。

CDH1 promoter methylation in patients with cervical carcinoma: a systematic meta-analysis with trial sequential analysis.

机构信息

Department of Gynaecology & Obstetrics, Beijing Chaoyang Hospital Affiliated to Capital Medical University, No. 8 Workers Stadium South Road, Beijing 100020, China.

出版信息

Future Oncol. 2018 Jan;14(1):51-63. doi: 10.2217/fon-2017-0267. Epub 2017 Dec 14.

DOI:10.2217/fon-2017-0267

PMID:29237293

Abstract

AIM

This study was performed to evaluate the correlation between CDH1 promoter methylation and cervical cancer.

METHODS

Trial sequential analysis was conducted to evaluate the required information size.

RESULTS

A total of 15 studies with 950 cervical cancers and 829 controls were identified. CDH1 promoter methylation was higher in cervical cancer than in cervical intraepithelial neoplasia lesions and normal cervical tissues. Subgroup analysis of ethnicity showed that CDH1 promoter methylation correlated with cervical cancer in Caucasians, but not in Asians. CDH1 promoter methylation was higher in cervical cancer cytology samples than in normal cytology samples. It was higher in squamous cell carcinoma than adenocarcinoma, but was not correlated with tumor stage, grade and overall survival.

CONCLUSION

CDH1 promoter methylation may be correlated with cervical cancer carcinogenesis, especially for Caucasians. It was associated with histological subtypes. Trial sequential analysis showed that more studies are needed.

摘要

目的

本研究旨在评估 CDH1 启动子甲基化与宫颈癌之间的相关性。

方法

采用试验序贯分析来评估所需的信息量。

结果

共纳入 15 项研究，包含 950 例宫颈癌和 829 例对照。与宫颈上皮内瘤变和正常宫颈组织相比，宫颈癌中 CDH1 启动子甲基化水平更高。亚组分析显示，CDH1 启动子甲基化与宫颈癌在高加索人群中相关，但在亚洲人群中不相关。宫颈癌细胞学样本中 CDH1 启动子甲基化水平高于正常细胞学样本。在鳞癌中高于腺癌，但与肿瘤分期、分级和总生存期无关。