Wolf M M, Cooper I A, Ding J C
Aust N Z J Med. 1979 Aug;9(4):398-402. doi: 10.1111/j.1445-5994.1979.tb04166.x.
Acute nonlymphocytic leukaemia developed in seven patients treated for Hodgkin's disease. All had received intensive radiotherapy and chemotherapy. One patient had clinical evidence of active Hodgkin's disease at the time of diagnosis of acute leukaemia, and of four other patients who had a post mortem examination another showed evidence of Hodgkin's disease. The median time from the first presentation with Hodgkin's disease to the development of acute leukaemia was 7.7 years. Chromosomal abnormalities were found in four patients. A preleukaemic phase was present in three patients. Survival following diagnosis of acute leukaemia was short (median four weeks) and only one patient achieved a complete remission. Although published data suggests that radiation exposure is an important aetiologic factor in the induction of acute leukaemia in patients with Hodgkin's disease, it appears likely that additional chemotherapy may have a significant potentiating effect.
7例接受霍奇金病治疗的患者发生了急性非淋巴细胞白血病。所有患者均接受了强化放疗和化疗。1例患者在急性白血病诊断时具有活动性霍奇金病的临床证据，在另外4例进行尸检的患者中，有1例显示有霍奇金病的证据。从首次出现霍奇金病到发生急性白血病的中位时间为7.7年。4例患者发现染色体异常。3例患者存在白血病前期。急性白血病诊断后的生存期较短（中位4周），只有1例患者实现完全缓解。尽管已发表的数据表明，辐射暴露是霍奇金病患者诱发急性白血病的重要病因，但额外的化疗似乎可能具有显著的增效作用。
